2-Aminothiazol-4-acetic Acid丨CAS 29676-71-9

2-Aminothiazol-4-acetic acid (CAS 29676-71-9) is a heterocyclic amino acid derivative widely used as an intermediate in pharmaceutical and agrochemical synthesis. Its 2-aminothiazole core with an acetic acid side chain makes it a versatile building block for the design of β-lactam antibiotics, enzyme inhibitors, and other bioactive compounds. In medicinal chemistry, it is applied in the synthesis of penicillin and cephalosporin analogues, where the aminothiazole ring enhances antibacterial activity and binding specificity. In agrochemicals, it serves as a precursor for herbicides, fungicides, and insecticides with improved efficacy. Additionally, it is used in organic synthesis to create functionalized heterocycles and study structure–activity relationships in drug development.

The benefits of 2-aminothiazol-4-acetic acid arise from its multifunctional reactivity and biologically relevant scaffold. The amino group allows selective derivatization, coupling, and condensation reactions, while the acetic acid moiety provides solubility and enables further functionalization. The aminothiazole ring contributes electronic and steric features that enhance binding affinity in biological targets. Its combination of reactivity, stability, and biological relevance makes it a highly adaptable intermediate for the efficient synthesis of antibiotics, agrochemicals, and other bioactive molecules.