2,3-Difluoro-6-methoxybenzaldehyde丨CAS 187543-87-9

2,3-Difluoro-6-methoxybenzaldehyde (CAS 187543-87-9) is a fluorinated aromatic aldehyde widely used as an intermediate in pharmaceutical, agrochemical, and fine chemical synthesis. The aldehyde group makes it highly reactive toward condensation, reductive amination, and cyclization reactions, enabling the construction of diverse heterocycles and substituted aromatic compounds. Its difluoro and methoxy substituents are particularly valuable in medicinal chemistry, where they are used to tune electronic properties, lipophilicity, and metabolic stability of drug candidates. The compound is commonly applied in structure–activity relationship studies, synthesis of enzyme inhibitors, receptor ligands, and fluorinated intermediates, as well as in the preparation of advanced materials and specialty chemicals requiring precise substitution patterns.

The benefits of 2,3-difluoro-6-methoxybenzaldehyde arise from its multifunctional structure and chemical stability. The presence of two fluorine atoms enhances metabolic stability and influences binding interactions in biologically active molecules, while the methoxy group improves solubility and modulates electronic effects on the aromatic ring. The aldehyde functionality allows efficient and selective downstream transformations under mild conditions, supporting high synthetic flexibility. The compound is compatible with a wide range of reagents and reaction conditions and is generally stable under standard storage, enabling reproducible synthesis and scale-up. These features make it a reliable building block for high-value fluorinated compounds.