1-(4-Hydroxyphenyl)piperazine丨CAS 56621-48-8

1-(4-Hydroxyphenyl)piperazine (CAS 56621-48-8) is an important heterocyclic intermediate widely used in pharmaceutical and medicinal chemistry. It serves as a building block for the synthesis of bioactive molecules, including central nervous system (CNS) agents, serotonin receptor modulators, and other therapeutic compounds. The hydroxyphenyl and piperazine moieties provide versatility for further derivatization, allowing its incorporation into ligands, enzyme inhibitors, and receptor-targeted molecules. It is also employed in research for structure–activity relationship (SAR) studies, facilitating the design and optimization of drug candidates, as well as in the synthesis of heterocyclic frameworks and functionalized aromatic compounds.

The benefits of 1-(4-Hydroxyphenyl)piperazine stem from its dual functional groups and chemical stability. The hydroxy group allows for hydrogen bonding, esterification, etherification, and other functional modifications, while the piperazine ring provides a basic nitrogen center for alkylation, acylation, and heterocycle formation. This combination enables the synthesis of structurally diverse molecules with high selectivity and controlled pharmacological properties. Its solubility in common organic solvents, chemical robustness, and compatibility with standard synthetic methods make it a practical intermediate for both laboratory research and industrial-scale pharmaceutical production.