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Specifications
| Appearance: | Off-white or white crystal |
| Assay(HPLC): | 98% min |
| Melting point: | 126°C - 132°C |
| Loss on drying: | 0.5% max |
Transport Information
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UN Number |
3261 |
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Class |
8 |
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Packing Group |
II |
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H.S. Code |
2933490090 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Inert atmosphere, 2-8°C |
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Applications
1. Organic Synthesis Reagent
Widely used as a sulfonylating agent to introduce sulfonamide or sulfonate groups into organic molecules.
Reacts with amines, alcohols, or thiols to form quinoline-based sulfonamides, sulfonates, and thioethers.
Serves as an intermediate in the synthesis of more complex pharmaceutical or agrochemical agents.
2. Pharmaceutical Research
Used in the synthesis of quinoline-derived biologically active compounds, such as anti-inflammatory, antibacterial, antiviral, or antimalarial agents.
Plays a role in medicinal chemistry research where the quinoline scaffold is modified for target-specific activity.
3. Agrochemical Intermediates
Involved in producing compounds with pesticidal, fungicidal, or herbicidal properties due to the bioactive nature of the quinoline core.
4. Material Science
Potentially used in the development of functionalized ligands, photoactive materials, or fluorescent tags, leveraging the quinoline ring's electronic properties.
Benefits
Versatile Reactivity: The sulfonyl chloride group is highly reactive and provides flexible synthetic utility in forming various functional groups.
Bioactive Core: The quinoline nucleus is a privileged structure in medicinal and agrochemical applications, enhancing the biological potential of its derivatives.
Selective Functionalization: Functionalization at the 8-position of quinoline offers regioselective advantages in designing target molecules.
Building Block Utility: Serves as a robust intermediate for designing and diversifying molecular libraries in research and development.
Conclusion
8-Quinolinesulfonyl chloride (CAS 18704-37-5) is a valuable synthetic intermediate widely used in the production of sulfonated quinoline derivatives. Its dual functionality-combining the quinoline ring and the reactive sulfonyl chloride group-makes it particularly useful in pharmaceutical, agrochemical, and material science research. As interest in quinoline-based scaffolds continues to grow for drug discovery and crop protection, this compound remains an essential reagent in modern chemical synthesis.
