1,10-Dichlorodecane丨CAS 2162-98-3

Overview

1,10-Dichlorodecane丨CAS 2162-98-3 is a long-chain α,ω-dihaloalkane, valued as a synthetic intermediate in organic and polymer chemistry.

Applications

1. Organic Synthesis Intermediate

Bifunctional Building Block:
The terminal chlorides make it an excellent bifunctional electrophile for nucleophilic substitution reactions, allowing for:

Cyclization (e.g. macrocycle synthesis)

Chain extensions and crosslinking

Formation of nitrogen, oxygen, or sulfur-linked derivatives

Precursor to Diamines, Diols, and Dithio Compounds:
When reacted with appropriate nucleophiles such as amines, alcohols, or thiols, it yields useful intermediates like:

1,10-diaminodecane

1,10-decanediol

1,10-dithioldecane

2. Polymer Chemistry

Monomer or Chain Extender:
Used in step-growth polymerizations and polycondensations to produce specialty polyamides, polyurethanes, or polyethers with flexible long-chain aliphatic segments.

Spacer or Linker Molecule:
The long, non-polar aliphatic chain can be used to modulate polymer flexibility, hydrophobicity, and mechanical properties.

3. Surfactants and Functional Materials

Intermediate in the synthesis of gemini surfactants and other amphiphilic molecules where spacing between polar head groups is important.

4. Macrocyclic and Supramolecular Chemistry

Due to its length and reactivity, 1,10-dichlorodecane can be used in macrocycle synthesis, including crown ethers, cryptands, and molecular cages via nucleophilic substitution and ring-closing reactions.

5. Pharmaceutical and Agrochemical Synthesis

Sometimes used as a hydrophobic linker in the preparation of bioactive molecules, including conjugates or prodrugs with long alkyl tails that improve membrane affinity or bioavailability.

Benefits

1. Dual Reactivity

The two terminal chlorine atoms enable symmetrical and bifunctional modifications, providing versatility in synthesis.

2. Long Aliphatic Chain

Acts as a flexible hydrophobic spacer, which is beneficial in designing molecules with amphiphilic or membrane-active properties.

3. Customizable Reactivity

Readily reacts with a wide variety of nucleophiles, allowing for easy chemical tailoring in multiple synthetic pathways.

4. Useful in Custom Polymer Design

Facilitates the design of tailored materials with desired mechanical, thermal, or surface characteristics, especially for specialty elastomers and coatings.

Conclusion

1,10-Dichlorodecane丨CAS 2162-98-3 is a versatile bifunctional intermediate widely used in organic synthesis, polymer chemistry, and materials science. Its long-chain structure and terminal reactivity make it ideal for the synthesis of extended or flexible molecules, specialty surfactants, and polymeric materials with tailored properties.