Poloxamer 188/182/407丨CAS 9003-11-6

Poloxamer 188/182/407 (CAS 9003-11-6) are nonionic polyoxyethylene-polyoxypropylene block copolymers with excellent surfactant, emulsifying, solubilizing, and stabilizing properties. Their amphiphilic structure enables them to improve the dispersion and stability of active ingredients, making them widely used in pharmaceutical, biotechnology, cosmetic, and industrial formulations.

Product Name: Poloxamer 188

CAS No.: 9003-11-6

CDE Registration No.: F20190001853 (A)

Pharmacopoeial Compliance: ChP / USP / EP

Storage: Store protected from light in a tightly closed container.

Product Specifications

In the copolymer, the number of oxyethylene units (a) is 75–85, while the number of oxypropylene units (b) is 25–30. The oxyethylene (EO) content is 79.9%–83.7%, with an average molecular weight of 7,680–9,510.

Product Features

Precision Polymerization Technology: Provides a narrow molecular weight distribution and excellent batch-to-batch consistency.

Low Unsaturation: Enhances product stability during storage and helps maintain consistent performance.

Low Impurity Content: Supports reliable and safe application in pharmaceutical formulations.

Applications

Poloxamer 188 is widely used in liquid oral and topical pharmaceutical formulations as an emulsifier, solubilizer, wetting agent, and suspension stabilizer. It can also be used as a plasticizer for coating materials in oral solid dosage forms, helping improve coating flexibility and formulation performance.

Product Name: Poloxamer 182

CAS No.: 9003-11-6

CDE Registration No.: F20230000463

Pharmacopoeial Compliance: EP

Appearance: Colorless to pale yellow viscous liquid. It may become cloudy when the temperature approaches its cloud point. Freely soluble in water.

Product Advantages

• Poloxamer 182 can improve the solubility and bioavailability of poorly water-soluble drugs through micelle formation.
• It offers excellent biocompatibility and safety, making it suitable for pharmaceutical formulations.
• As a relatively uncommon grade in the domestic market, Poloxamer 182 has stronger lipophilicity compared with other Poloxamer grades, providing additional flexibility for formulation development.

Applications

01 | Dosage Form: Topical Gels
Application: Surfactant

02 | Dosage Forms: Foams, Sprays & Creams
Application: Emulsifier

Product Name: Poloxamer 407 (P407)

CAS No.: 9003-11-6

Molecular Weight: 9,840–14,600

Appearance: White to off-white waxy solid with a slight odor. Freely soluble in water and ethanol, and insoluble in propylene glycol.

Product Introduction

Poloxamer 407 features a unique amphiphilic structure that provides excellent temperature responsiveness and self-assembly properties. Its critical micelle concentration (CMC) is related to the PEO and PPO content of the polymer; increasing the PPO content generally results in a lower CMC. Its gelation temperature is also concentration-dependent. Among the various Poloxamer grades, P407 has been extensively studied because a concentration of approximately 20% can form a gel at 25°C, which is lower than the concentration typically required by other Poloxamer grades. In addition, P407 offers good biocompatibility and biodegradability and has been approved by the U.S. FDA for human use.

Applications

Hydrophobic Drug Solubilization: Forms micelles that improve the solubility and bioavailability of poorly water-soluble drugs.

Controlled & Sustained Release: Forms thermoreversible gels at body temperature, making it an effective carrier for prolonged drug delivery.

Emulsifier: Provides good emulsification and formulation stability for pharmaceutical preparations, including certain injectable formulations.

Wound Healing: Helps protect cell membranes and may support tissue repair, cell proliferation, and wound healing.