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Specifications of methyl cyclodextrin丨CAS 51166-71-3
|
Property |
Specification |
|
Appearance |
White or almost white powder; Odorless, slightly sweet; Freely soluble in water, soluble in methanol and ethanol |
|
Assay (on the dried basis) |
98% min |
|
Specific rotation |
+154° to +165° |
|
Water solution pH |
5 to 7.5 |
|
Clarity of solution |
2.5g/25ml water solution is clear |
|
Light-absorbing impurities |
Between 230 nm and 350 nm, the absorbance is not greater than 1.0; Between 350 nm and 750 nm, the absorbance is not greater than 0.1 |
|
Average degree of substitution |
7 to 13.3 |
|
Loss on drying |
7% max |
|
Beta cyclodextrin |
0.2% max |
|
Residue on ignition |
0.5% max |
|
Heavy metal |
10 ppm |
|
Sulfate |
0.2% max |
|
Chloride |
0.2% max |
|
Total aerobic microbial count |
1000 cfu/g max |
|
Total combined molds and yeasts count |
100 cfu/g max |
|
Escherichia coli |
Absence |
|
Packaging and storage |
Preserve in well-closed container |
Introduction of methyl cyclodextrin丨CAS 51166-71-3
Methyl cyclodextrin丨CAS 51166-71-3 (MCD) is a modified cyclodextrin where methyl groups are attached to the hydroxyl groups of the cyclodextrin structure. This modification enhances its solubility and interaction properties compared to natural cyclodextrins. Here are the primary applications and benefits of methyl cyclodextrin:
Applications of methyl cyclodextrin丨CAS 51166-71-3
1. Pharmaceuticals:
- Drug Delivery and Solubilization: methyl cyclodextrin丨CAS 51166-71-3 is used to enhance the solubility and stability of poorly soluble drugs. It forms inclusion complexes with drug molecules, improving their bioavailability and effectiveness.
- Cell Membrane Permeabilization: Methyl cyclodextrin can be used to temporarily permeabilize cell membranes, which is useful in drug delivery and gene therapy applications.
2. Cosmetics and Personal Care:
- Ingredient Stabilization: Methyl cyclodextrin helps stabilize sensitive cosmetic ingredients such as vitamins, essential oils, and peptides, extending the shelf life and efficacy of cosmetic products.
- Controlled Release: It is used in controlled-release formulations in skincare products, allowing for the sustained delivery of active ingredients.
3. Food and Beverages:
- Flavor and Aroma Enhancement: Methyl cyclodextrin is employed to encapsulate and stabilize flavors and aromas, ensuring they are preserved throughout the shelf life of food and beverage products.
- Nutrient Delivery: It can be used to enhance the delivery and effectiveness of nutrients and bioactive compounds in food products.
4. Environmental Applications:
- Pollutant Removal: Methyl cyclodextrin is used in environmental remediation to encapsulate and remove pollutants and contaminants from water and soil.
5. Analytical Chemistry:
- Chromatography and Separation: Methyl cyclodextrin is utilized as a chiral selector in chromatography for the separation and analysis of enantiomers, providing high-resolution separation of optical isomers.
6. Industrial Processes:
- Catalysis and Separation: Methyl cyclodextrin is used in various industrial applications, including catalysis and separation processes, where it can act as a medium for selective separation and reactions.
Benefits of methyl cyclodextrin丨CAS 51166-71-3
1. Enhanced Solubility and Bioavailability:
- Improved Drug Delivery: Methyl cyclodextrin increases the solubility and stability of poorly soluble drugs, enhancing their bioavailability and therapeutic efficacy.
2. Ingredient Stabilization:
- Extended Shelf Life: It stabilizes sensitive ingredients in cosmetics and food products, helping to extend their shelf life and maintain their effectiveness.
3. Flavor and Aroma Preservation:
- Improved Sensory Experience: By encapsulating and stabilizing flavors and aromas, methyl cyclodextrin ensures that they remain effective and enhance the sensory experience of food and beverages.
4. Controlled Release:
- Sustained Effects: methyl cyclodextrin丨CAS 51166-71-3 enables controlled release of active ingredients, providing sustained therapeutic or cosmetic effects.
5. Pollutant Removal:
- Environmental Benefits: The ability to encapsulate and remove pollutants makes methyl cyclodextrin valuable in environmental cleanup and remediation efforts.
6. Chiral Separation:
- Precise Analysis: In analytical chemistry, methyl cyclodextrin allows for precise separation and analysis of enantiomers, which is crucial for determining the purity and composition of chiral compounds.
Precautions and Considerations:
1. Dosage and Formulation:
- Optimization Required: The effectiveness of methyl cyclodextrin depends on its concentration and formulation. Proper optimization is necessary to achieve desired effects in various applications.
2. Regulatory Status:
- Approval and Standards: The use of methyl cyclodextrin in pharmaceuticals, food, and cosmetics must comply with relevant regulatory standards and guidelines to ensure safety and efficacy.
3. Compatibility:
- Interactions with Other Ingredients: In formulations, it is important to ensure that methyl cyclodextrin is compatible with other ingredients and does not affect their stability or efficacy.
4. Cost Considerations:
- Economic Feasibility: The cost of producing and incorporating methyl cyclodextrin into products may impact its economic feasibility, especially for large-scale applications.
Conclusion:
methyl cyclodextrin丨CAS 51166-71-3 is a versatile compound with significant applications and benefits in pharmaceuticals, cosmetics, food and beverages, environmental remediation, and analytical chemistry. Its ability to enhance solubility, stabilize ingredients, and facilitate controlled release makes it valuable in a wide range of industries. However, careful consideration of dosage, formulation, and regulatory compliance is essential to maximize its benefits and ensure effective use.
