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Specifications of Perindopril erbumine丨107133-36-8
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Parameter |
Specification |
|
Description |
White or almost white crystalline powder, slightly hygroscopic |
|
Assay by titrimetry |
99.0 to 101.0% on anhydrous basis |
|
Solubility |
|
|
Water & Ethanol (96%) |
Freely soluble |
|
Methylene chloride |
Soluble or sparingly soluble |
|
Alcohol |
Freely soluble |
|
Methylene chloride (Alternative) |
Sparingly soluble |
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Identification |
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|
Specific Optical Rotation |
-66° to -69° |
|
IR |
Similar to the reference standard |
|
TLC |
Similar to the reference standard |
|
Impurities |
|
|
Impurity A (By TLC) |
0.25% max |
|
Related Substances (HPLC) |
|
|
Impurity B |
0.3% max |
|
Impurity E |
0.4% max |
|
Impurity F |
0.2% max |
|
Impurity H |
0.2% max |
|
Impurity I |
0.2% max |
|
Any other unknown impurity |
0.1% max |
|
Total impurities |
1.0% max |
|
Water (K.F) |
1.0% max |
|
Sulphated Ash |
0.1% max |
|
Heavy Metals |
20 ppm max |
|
Particle Size d(0.9) |
75μm max |
|
Residual Solvents |
|
|
Methylene chloride |
0.06% max |
|
Ethyl acetate |
0.5% max |
|
Cyclohexane |
0.388% max |
|
Tetrahydrofuran |
0.072% max |
|
Acetonitrile |
0.041% max |
|
Pyridine |
0.02% max |
Transport Information of Perindopril erbumine丨107133-36-8
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Parameter |
Specification |
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UN Number |
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|
Class |
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Packing Group |
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H.S. Code |
2933990099306 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions (room temperature). |
|
Storage |
Tightly closed. Dry. Keep locked up. 2-8℃ |
|
Condition to Avoid |
|
|
Package |
As requested |
Manufacturing Information of Perindopril erbumine丨107133-36-8
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Parameter |
Specification |
|
Capacity |
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|
Frequency |
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Main Export Countries |
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Capacity/Batch |
100kg/batch |
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Experience |
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Stock |
Applications of Perindopril erbumine丨107133-36-8
Hypertension Treatment
Perindopril erbumine丨107133-36-8 is an angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure (hypertension). By relaxing blood vessels, it helps lower blood pressure and reduces the risk of heart-related complications.
Heart Failure Management
It is prescribed to patients with congestive heart failure to improve heart function and reduce symptoms such as shortness of breath and fluid retention.
Prevention of Cardiovascular Diseases
Perindopril erbumine is used to reduce the risk of heart attacks, strokes, and other cardiovascular conditions, especially in patients with a history of heart disease.
Chronic Kidney Disease Treatment
It helps protect kidney function in patients with diabetes and chronic kidney disease by reducing proteinuria (excess protein in urine) and lowering blood pressure.
Post-Stroke Therapy
Perindopril erbumine is sometimes included in treatment plans for patients recovering from strokes to lower the risk of future cardiovascular events.
Benefits of Perindopril erbumine丨107133-36-8
Effective Blood Pressure Control
By inhibiting ACE, it helps lower blood pressure and improves overall cardiovascular health.
Improves Heart Function
It reduces strain on the heart, making it an essential medication for managing heart failure and preventing complications.
Kidney Protection
For diabetic and hypertensive patients, it helps preserve kidney function by reducing damage caused by high blood pressure.
Stroke and Heart Attack Prevention
Long-term use significantly lowers the risk of recurrent strokes and heart attacks, especially in high-risk patients.
Well-Tolerated with Proven Efficacy
It is generally well-tolerated with fewer side effects compared to some other blood pressure medications, making it a preferred choice for long-term cardiovascular protection.
Conclusion
Perindopril erbumine丨107133-36-8 is a widely used ACE inhibitor with applications in hypertension, heart failure, kidney protection, and cardiovascular disease prevention. Its ability to lower blood pressure, protect the heart, and reduce the risk of major cardiovascular events makes it a vital medication for managing chronic health conditions.
