Cobamamide丨CAS 13870-90-1

Cobamamide丨CAS 13870-90-1, also known as adenosylcobalamin or coenzyme B12, is one of the active coenzyme forms of vitamin B12. Unlike cyanocobalamin or hydroxocobalamin, which are precursors, cobamamide is biologically active without conversion and directly participates in essential enzymatic reactions within the body. It plays a crucial role in cellular metabolism, particularly in the metabolism of amino acids and fatty acids, and in the synthesis of DNA and red blood cells. Because of its vital role in energy production and neurological function, cobamamide is used in pharmaceutical, nutraceutical, and clinical nutrition applications.

1. Pharmaceutical Use
Cobamamide丨CAS 13870-90-1 is widely used in pharmaceutical preparations for treating and preventing vitamin B12 deficiency, especially in cases where rapid and direct biological activity is needed.
● Treatment of anemia: Effective in treating megaloblastic anemia caused by B12 deficiency.
● Neurological disorders: Used to manage peripheral neuropathy, neuritis, and neuralgia due to its role in maintaining myelin sheath integrity.
● Support in chronic diseases: Used as part of supportive therapy in chronic liver diseases, diabetes-related nerve disorders, and metabolic syndromes.
● Parenteral and oral forms: Available in injectable and oral formulations for direct administration and absorption.
2. Clinical Nutrition and Supplementation
Cobamamide is incorporated into dietary supplements and clinical nutrition products where an active form of B12 is desired for rapid or efficient utilization.
● Nutritional support for vegetarians/vegans: Individuals on plant-based diets are often deficient in B12, and cobamamide can serve as a potent supplement.
● Elderly nutrition: Used in formulations targeting seniors who may have reduced B12 absorption due to age-related decline in intrinsic factor.
● Fatigue and cognitive support: Promoted in energy-boosting and nootropic supplements due to its involvement in ATP production and neurological health.
3. Metabolic and Genetic Disorders
Cobamamide is used in the management of rare inborn errors of metabolism, such as:
● Methylmalonic acidemia: A genetic condition where the body cannot properly process certain fats and proteins; cobamamide helps correct the metabolic pathway.
● Inherited B12 absorption disorders: For patients who lack the enzymes or transport proteins to convert B12 precursors into their active forms.
4. Cosmetic and Dermatological Products
Due to its cell-regenerating and anti-inflammatory properties, cobamamide may be found in specialized skin care formulations or injections aimed at revitalizing the skin or managing dermatological disorders like eczema or dermatitis caused by B12 deficiency.

1. Direct Bioavailability
Unlike other B12 forms (such as cyanocobalamin, which requires enzymatic conversion), cobamamide is immediately active, allowing for rapid therapeutic action, especially useful in acute deficiencies or metabolic emergencies.
2. Neurological Health
Cobamamide丨CAS 13870-90-1 is essential for the maintenance of the nervous system, particularly through its role in myelin synthesis. It supports nerve regeneration and may help relieve symptoms of neuropathy, paresthesia, and muscle weakness.
3. Supports Energy Production
As a participant in mitochondrial energy metabolism, cobamamide enhances ATP production, reducing fatigue and boosting physical and mental performance. It is especially beneficial for individuals suffering from chronic fatigue, burnout, or debilitating illness.
4. DNA and Red Blood Cell Synthesis
Cobamamide aids in the synthesis of nucleic acids and red blood cells, making it crucial for growth, development, and tissue repair. Its deficiency can lead to macrocytic anemia, which is characterized by larger-than-normal red blood cells that are fewer in number.
5. Safe and Well-Tolerated
Cobamamide is generally well-tolerated, with a low risk of side effects when used appropriately. It is safe even in relatively high doses and is not known to accumulate to toxic levels due to its water-soluble nature and efficient renal clearance.

Conclusion
Cobamamide丨CAS 13870-90-1 is a highly bioactive and effective coenzyme form of vitamin B12, essential for energy metabolism, neurological function, and cell regeneration. Its broad range of applications in medicine, nutrition, and metabolic therapy stems from its unique ability to act directly in physiological processes without conversion. For individuals with B12 deficiencies, neurological disorders, or metabolic conditions, cobamamide offers fast and effective support, making it an invaluable compound in both therapeutic and preventive health care.