Cefuroxime Sodium丨CAS 56238-63-2

Cefuroxime sodium丨CAS 56238-63-2 is the sodium salt form of cefuroxime, a second-generation cephalosporin antibiotic. It is a broad-spectrum β-lactam antimicrobial agent used primarily for parenteral administration (i.e., intravenous or intramuscular). Cefuroxime sodium is a white to off-white crystalline powder that is highly soluble in water and commonly supplied as an injectable formulation. Its broad antimicrobial activity, good safety profile, and stability make it a critical tool in clinical infection management.

1. Treatment of Bacterial Infections
Cefuroxime sodium is effective against a wide range of Gram-positive and Gram-negative bacteria, making it suitable for treating numerous infections, including:
● Respiratory tract infections
o Pneumonia
o Bronchitis (acute exacerbations of chronic bronchitis)
● Ear, nose, and throat infections
o Sinusitis
o Otitis media
● Urinary tract infections (UTIs)
o Cystitis
o Pyelonephritis
● Skin and soft tissue infections
o Cellulitis
o Abscesses
● Bone and joint infections
o Osteomyelitis
o Septic arthritis
● Gynecological infections
o Pelvic inflammatory disease
o Endometritis
2. Surgical Prophylaxis
Cefuroxime sodium丨CAS 56238-63-2 is frequently used as a prophylactic antibiotic to prevent postoperative infections, especially in:
● Abdominal surgery
● Orthopedic procedures
● Cardiothoracic surgery
● Gynecological and obstetric surgery
Its quick onset and reliable spectrum make it a standard choice for short-term infection prevention in sterile procedures.
3. Hospital-Acquired Infections
Used in clinical settings to manage infections in immunocompromised patients or those in intensive care, such as:
● Ventilator-associated pneumonia
● Catheter-associated UTIs
● Surgical site infections
4. Pediatric Use
Safe and effective for children in treating various bacterial infections, particularly those of the ear, throat, and respiratory tract.

1. Broad-Spectrum Activity
Cefuroxime sodium covers a wide array of organisms including:
● Gram-positive: Staphylococcus aureus (methicillin-sensitive), Streptococcus pneumoniae
● Gram-negative: Haemophilus influenzae, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Neisseria gonorrhoeae
This broad activity reduces the need for combination therapy in many cases.
2. β-Lactamase Stability
Unlike many first-generation cephalosporins, cefuroxime is resistant to several common β-lactamases produced by resistant bacteria, enhancing its effectiveness against many strains of H. influenzae and N. gonorrhoeae.
3. Favorable Pharmacokinetics
● Rapid absorption and distribution
● Good tissue penetration, including into bone, joint fluid, and bile
● Short half-life (~1 hour), making dosing predictable and flexible
● Achieves therapeutic levels quickly, especially via intravenous route
4. Safety and Tolerability
Cefuroxime sodium丨CAS 56238-63-2 has a favorable safety profile with generally mild side effects, such as:
● Gastrointestinal disturbances (nausea, diarrhea)
● Injection site reactions
● Rare hypersensitivity or allergic reactions
Its well-established clinical record makes it a preferred choice in both adult and pediatric populations.
5. Effective Alternative to Penicillin
Cefuroxime sodium is often used in patients with mild to moderate penicillin allergies (except for those with a history of severe anaphylaxis), providing a reliable alternative with a similar mechanism of action.
6. Useful Against Resistant Organisms
Cefuroxime retains efficacy against several strains that have developed resistance to older antibiotics, making it useful in settings with rising antimicrobial resistance.
7. Multiple Routes of Administration
While cefuroxime sodium is primarily for injection, its oral prodrug, cefuroxime axetil, allows seamless transition from IV to oral therapy during hospital discharge, ensuring treatment continuity.

Cefuroxime sodium丨CAS 56238-63-2 is a potent, broad-spectrum, and safe second-generation cephalosporin antibiotic used widely in both treatment and prevention of bacterial infections. Its β-lactamase resistance, excellent tissue penetration, and tolerability make it especially valuable in hospital settings, surgical prophylaxis, and serious infections requiring injectable antibiotics. With the ongoing threat of antimicrobial resistance, cefuroxime sodium continues to be a key agent in modern antibiotic therapy.