Latanoprost丨CAS 130209-82-4

Latanoprost丨CAS 130209-82-4 is a synthetic prostaglandin F2α analogue primarily used in ophthalmology. It is most widely known for its efficacy in treating elevated intraocular pressure (IOP) in conditions such as open-angle glaucoma and ocular hypertension. By mimicking natural prostaglandins in the eye, latanoprost facilitates fluid drainage and reduces pressure inside the eye, which helps prevent optic nerve damage and vision loss.

1. Treatment of Glaucoma and Ocular Hypertension
● Primary use: Latanoprost丨CAS 130209-82-4 is a first-line medication in the management of open-angle glaucoma, the most common form of glaucoma worldwide. It reduces intraocular pressure, which is the primary modifiable risk factor in glaucoma progression.
● Mechanism of action: It increases the outflow of aqueous humor through the uveoscleral pathway without significantly affecting its production, offering a gentle and effective pressure-lowering effect.
2. Combination Therapy
● Used with other agents: Latanoprost is often combined with beta-blockers (e.g., timolol) or carbonic anhydrase inhibitors for patients who require additional IOP reduction beyond what monotherapy can achieve.
● Fixed-combination products: Commercial formulations combining latanoprost with other agents enhance patient compliance by reducing dosing frequency.
3. Off-Label and Cosmetic Use
● Eyelash enhancement: Due to its effect on hair follicle stimulation, latanoprost and related prostaglandin analogs have been studied and used off-label for eyelash growth (e.g., in alopecia or hypotrichosis).
● Potential for hair regrowth: Investigational studies are exploring latanoprost's ability to stimulate scalp hair growth, although it is not approved for this use.

1. Effective Intraocular Pressure Reduction
● Latanoprost丨CAS 130209-82-4 provides consistent and significant reduction in IOP with once-daily dosing, typically lowering pressure by 25–35%.
● Its effect lasts for 24 hours, making it suitable for evening administration and improving compliance.
2. Favorable Safety and Tolerability
● Most patients tolerate latanoprost well, with minimal systemic side effects due to its topical application.
● It does not adversely affect heart rate, blood pressure, or respiratory function, unlike some systemic glaucoma medications.
3. Neuroprotective Potential
● Some studies suggest that prostaglandin analogs like latanoprost may offer neuroprotective benefits to the optic nerve, though this is still under investigation.
4. Convenient Dosing
● Once-daily use (typically at night) promotes adherence to treatment regimens, which is critical for managing chronic conditions like glaucoma.
5. Global Accessibility
● Latanoprost is available as both a brand-name (e.g., Xalatan) and generic product, improving affordability and access to treatment worldwide.