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Specifications of Bimatoprost丨CAS 155206-00-1
|
Property |
Specification |
|
Appearance |
White powder |
|
Purity (HPLC) |
99.0~101.0% |
|
Identification |
By HPLC, IR |
|
Solubility |
Very soluble in ethanol, methanol; sparingly to slightly soluble in water |
|
Residue on Ignition |
0.1% max |
|
Heavy Metals |
10 ppm max |
|
Optical Rotation |
+33~+37° (C=2 in CH3OH) |
|
Water |
1.0% max |
|
15β-Bimatoprost |
0.2% max |
|
15-Keto Derivative |
0.2% max |
|
5,6-trans Isomer |
0.2% max |
|
Any Other Impurity |
0.1% max |
|
Total Other Impurities |
0.5% max |
|
n-Hexane |
0.029% max |
|
Ethanol |
0.5% max |
|
Ether |
0.5% max |
|
Acetic Ether |
0.5% max |
Transport Information of Bimatoprost丨CAS 155206-00-1
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Parameter |
Specification |
|
UN Number |
|
|
Class |
|
|
Packing Group |
|
|
H.S. Code |
2937500090999 |
|
Stability & Reactivity |
The product is chemically stable under standard ambient conditions (room temperature). |
|
Storage |
-20 deg.C |
|
Condition to Avoid |
|
|
Package |
Applications of Bimatoprost丨CAS 155206-00-1
Bimatoprost丨CAS 155206-00-1 is a synthetic prostaglandin analog, specifically a prostamide, widely used in ophthalmology and cosmetic dermatology due to its unique ability to influence both intraocular pressure (IOP) and hair follicle growth.
1. Treatment of Glaucoma and Ocular Hypertension
● Primary medical use: Bimatoprost丨CAS 155206-00-1 is approved for reducing elevated IOP in patients with open-angle glaucoma or ocular hypertension.
● Mechanism: It enhances aqueous humor outflow through both the uveoscleral and trabecular meshwork pathways, making it one of the most potent agents in its class for IOP reduction.
2. Cosmetic Use – Eyelash Enhancement
● FDA-approved as Latisse®: Bimatoprost is used topically to increase the length, thickness, and darkness of eyelashes in individuals with hypotrichosis.
● Aesthetic dermatology: It's also being studied and used off-label for eyebrow and scalp hair growth applications.
3. Investigational Uses
● Hair regrowth: Research is ongoing into its potential for treating androgenetic alopecia (pattern hair loss), where bimatoprost shows promise due to its follicle-stimulating properties.
Benefits of Bimatoprost丨CAS 155206-00-1
1. Superior IOP Reduction
● Bimatoprost丨CAS 155206-00-1 typically reduces IOP by 25–33%, comparable or superior to other prostaglandin analogs like latanoprost or travoprost.
● It is particularly useful in patients who are non-responsive to other glaucoma medications.
2. Dual Outflow Mechanism
● Unlike most prostaglandin analogs, bimatoprost increases aqueous humor outflow via two pathways, enhancing its efficacy.
3. Eyelash Growth Effects
● Proven efficacy in cosmetic enhancement of eyelashes, with visible results in 8–16 weeks when applied topically to the lash line.
● Encourages natural growth, not a cosmetic cover-up, and results typically persist with continued use.
4. Well-Tolerated and Convenient
● Administered once daily, improving patient adherence.
● Most side effects are localized (e.g., eye redness, darkening of eyelids or iris), with minimal systemic exposure.
5. Versatility in Formulation
● Available in both ophthalmic solution and topical cosmetic formats, addressing diverse patient needs.
