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Specifications
| Appearance: | Colorless liquid |
| Assay (GC): | 98.5% min. |
Transport Information
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Parameter |
Specification |
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UN Number |
3277 |
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Class |
6:; 8 |
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Packing Group |
II |
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H.S. Code |
2915900090 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
|
Storage |
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store in cool place. |
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Condition to Avoid |
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Package |
Applications
1. Organic Synthesis Intermediate
Used primarily as a protecting group reagent in organic synthesis.
Protects amino groups as carbamates via reaction with amines, enabling selective reactions on multifunctional molecules.
The 2,2,2-trichloroethyl group can be cleaved reductively, allowing temporary protection.
2. Pharmaceutical Synthesis
Applied in the synthesis of pharmaceutical intermediates where protection/deprotection strategies are critical.
Facilitates the synthesis of complex molecules by preventing side reactions on amine functionalities.
3. Peptide Chemistry
Utilized to protect amino groups during peptide synthesis, allowing stepwise construction of peptides without undesired side reactions.
4. Polymer and Material Chemistry
Employed in the synthesis of functionalized polymers and monomers where carbamate groups impart desirable properties.
Benefits
Effective Protecting Group: Provides robust protection for amines under diverse reaction conditions.
Selective and Reversible: The 2,2,2-trichloroethyl group can be removed under mild reductive conditions, making it a practical choice.
Improves Synthetic Efficiency: Enables multi-step synthesis by preventing unwanted reactions.
Compatibility: Compatible with various organic solvents and reagents.
Conclusion
2,2,2-Trichloroethyl chloroformate (CAS 17341-93-4) is a specialized reagent used mainly as a protecting group agent in organic and pharmaceutical synthesis. Its ability to selectively protect amino groups and be cleaved under mild conditions makes it invaluable for complex multi-step syntheses, including peptide production. Despite its reactivity, it enables improved efficiency and selectivity when handled with appropriate safety measures.
