Hangzhou Leap Chem Co., Ltd. is one of the most professional manufacturers and suppliers of l-2,4-dichlorophenylalanine丨cas 111119-36-9 in China. Welcome to wholesale bulk high quality chemical products at competitive price from our factory. If you have any enquiry about custom service, please feel free to email us.
Bulk Order L-2,4-Dichlorophenylalanine丨CAS 111119-36-9
L-2,4-Dichlorophenylalanine is a non-standard amino acid featuring two chlorine substituents at the 2- and 4-positions of the aromatic ring. Its L-configuration and dichlorinated phenyl side chain provide distinctive structural characteristics for peptide synthesis, medicinal chemistry, and advanced organic synthesis. The two chlorine substituents can influence the molecule's electronic properties, steric profile, and lipophilicity, making this compound a useful building block for researchers investigating modified peptides and structurally diverse amino acid derivatives.
Chemical Identifiers
| InChI | InChI=1S/C9H9Cl2NO2/c10-6-2-1-5(7(11)4-6)3-8(12)9(13)14/h1-2,4,8H,3,12H2,(H,13,14)/t8-/m0/s1 |
| InChI Key | GWHQTNKPTXDNRM-QMMMGPOBSA-N |
| Smiles | C1=CC(=C(C=C1Cl)Cl)C[C@@H](C(=O)O)N |
| EC No. | |
| MDL No. | MFCD05227922 |
| PubChem CID | 2761497 |
Applications
Solid-Phase Peptide Synthesis
L-2,4-Dichlorophenylalanine can be incorporated into suitable peptide sequences to introduce a dichlorinated aromatic side chain while retaining the L-configuration. Replacing conventional phenylalanine with this modified amino acid allows researchers to explore how multiple halogen substituents affect peptide conformation, stability, and molecular interactions. Its suitability for a specific synthesis depends on the coupling method, reaction conditions, and compatibility with the other amino acids and reagents involved.
Pharmaceutical and Medicinal Chemistry Research
Halogenated amino acids are useful building blocks in medicinal chemistry because halogen substitution can modify molecular lipophilicity, electronic distribution, and interactions with biological targets. L-2,4-Dichlorophenylalanine may support the preparation of modified peptides and amino-acid-derived compounds for structure–activity relationship studies. Researchers can compare dichlorinated structures with mono-chlorinated or non-halogenated analogues to investigate how substitution patterns influence molecular properties and biological activity.
Organic Synthesis and Chemical Research
Modified Peptide and Structure–Activity Studies
Non-standard amino acids provide researchers with opportunities to examine the relationship between molecular structure and biological function. L-2,4-Dichlorophenylalanine can introduce a specifically substituted aromatic side chain into suitable peptide or small-molecule designs. Comparisons with other dichlorophenylalanine isomers can help researchers investigate the effects of chlorine position on molecular recognition, conformation, and physicochemical properties, subject to experimental validation.
