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Specifications
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | 98% min |
| Specific rotation | -49.5±1.5° |
| Water (K.F) | 1.0% max |
Applications
Glycyl-L-alanine (CAS 3695-73-6) is a dipeptide composed of glycine and L-alanine linked via a peptide bond. It serves as an important model compound for studying peptide bond formation, enzymatic hydrolysis, and transport mechanisms of small peptides in biological systems. In biochemical and pharmaceutical research, it is used as a substrate to investigate the activity of peptidases and transport proteins such as PEPT1 and PEPT2, which are responsible for peptide absorption in the intestines and kidneys. Additionally, Glycyl-L-alanine plays a role in drug formulation and delivery research as a model compound for peptide-based prodrugs, where the dipeptide linkage is enzymatically cleaved to release active agents. It is also used in cell culture media and biochemical assays to study protein metabolism, peptide uptake, and enzyme kinetics.
Benefits
The main advantages of Glycyl-L-alanine lie in its simplicity, stability, and representativeness as a dipeptide model. Its well-defined structure makes it ideal for investigating peptide-related chemical and biological phenomena without the complexity of larger peptides or proteins. It exhibits good solubility in water and can easily be synthesized or obtained with high purity, making it practical for experimental and industrial use. The compound also offers low toxicity and compatibility with biological systems, ensuring accurate results in physiological studies. In pharmaceutical research, Glycyl-L-alanine aids in understanding drug absorption pathways and improving oral bioavailability through peptide transporter targeting.
Conclusion
Glycyl-L-alanine is a fundamental dipeptide widely utilized in biochemical, pharmaceutical, and physiological research. Its straightforward structure and versatile applicability make it an excellent model for peptide studies, enzyme kinetics, and transporter mechanisms. By bridging the gap between amino acids and larger peptides, Glycyl-L-alanine contributes significantly to our understanding of protein metabolism, peptide-based therapeutics, and drug delivery systems.
