2-Fluorophenylboronic Acid丨CAS 1993-03-9

2-Fluorophenylboronic acid (CAS 1993-03-9) is an organoboronic acid widely used as a key intermediate in organic synthesis, particularly in applications involving carbon–carbon bond formation. It plays an important role in the preparation of pharmaceuticals, agrochemicals, functional materials, and fine chemicals. The compound is commonly employed in Suzuki–Miyaura cross-coupling reactions to construct biaryl structures or introduce fluorinated aromatic units into complex molecules. Its fluorine substituent provides valuable electronic and steric characteristics that help researchers design molecules with enhanced stability, bioactivity, or material performance. It is also used in assembling heterocycles, polymers, ligands, and advanced intermediates required in research and industrial development.

The benefits of 2-fluorophenylboronic acid stem from its combination of reliable reactivity, high selectivity, and the useful influence of the fluorine atom on target molecule properties. The compound participates efficiently in cross-coupling reactions, often delivering high yields and clean reaction profiles, which improves synthetic efficiency and reduces purification burdens. The fluorine substituent can enhance metabolic stability, alter electronic distribution, and optimize binding interactions, making it highly advantageous in medicinal chemistry. Its boronic acid functionality offers versatility for a wide range of transformations, enabling researchers to tailor molecular frameworks with precision. Additionally, its stability and compatibility with standard reaction conditions make it practical for both laboratory-scale experimentation and industrial-scale synthesis.