Chloramphenicol-d5丨CAS 202480-68-0

Chloramphenicol-d5丨CAS 202480-68-0
Product Introduction:
CAS No.: 202480-68-0
Product Name: Chloramphenicol-d5
Molecular Formula: C11H12Cl2N2O5
Molecular Weight: 328.16
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Technical Parameters
Description

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Chloramphenicol-d5 is a deuterium-labeled form of chloramphenicol containing five deuterium atoms. As an isotopically labeled analogue of the antibiotic chloramphenicol, it is primarily used in analytical chemistry, pharmaceutical research, and method development for the identification and quantification of chloramphenicol. Its mass difference from the non-labeled compound makes it a useful candidate for stable-isotope dilution analysis and mass spectrometry applications.

 

Chemical Identifiers

 

InChI InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1/i1D,2D,3D,4D,9D
InChI Key WIIZWVCIJKGZOK-CJBPKKHQSA-N
Smiles [2H]C1=C(C(=C(C(=C1[C@]([2H])([C@@H](CO)NC(=O)C(Cl)Cl)O)[2H])[2H])[N+](=O)[O-])[2H]
EC No. 632-585-9
MDL No. MFCD18384950
PubChem CID 71312380

 

 

 

Applications

 

LC-MS/MS and Quantitative Analysis

Chloramphenicol-d5 can be used as an isotopically labeled internal standard in suitable liquid chromatography–tandem mass spectrometry (LC-MS/MS) methods. When validated for the target matrix and analytical conditions, it can help compensate for variations in sample preparation, instrument response, and matrix effects, supporting reliable chloramphenicol quantification.

Food Safety and Residue Analysis

Chloramphenicol residue monitoring is important in food safety testing, particularly for products of animal origin. Chloramphenicol-d5 can support the development, validation, and quality control of analytical methods used to detect and quantify chloramphenicol residues in suitable food matrices.

Pharmaceutical Analytical Research

In pharmaceutical analysis, isotopically labeled analogues can help researchers develop and validate quantitative methods for active compounds and related substances. Chloramphenicol-d5 may serve as a reference or internal-standard material in analytical workflows designed to measure chloramphenicol in pharmaceutical preparations and other appropriate samples.

Bioanalytical Method Development

Stable-isotope-labeled compounds are valuable in bioanalytical research because they can provide a distinguishable signal while often exhibiting similar analytical behavior to the target analyte. Chloramphenicol-d5 may support method development for measuring chloramphenicol in biological matrices, subject to validation of its performance, isotopic purity, and suitability for the specific assay.

 

 

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