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Specifications
| Appearance | Yellow powder |
| Purity(HPLC) | Rhein :98%min |
| Physical characteristics | |
| Particle-size | 100% 80mesh min |
| Weight loss | 2.0%max |
| Heavy metal | |
| Total metals | 10.0ppm max |
| Lead | 1.0ppm max |
| Mercury | 1.0ppm max |
| Cadmium | 0.5ppm max |
| Microorganism | |
| Total number of bacteria | 1000cfu/g max |
| Yeast | 100cfu/g max |
| Escherichia coli | Not included |
| Salmonella | Not included |
| Staphylococcus | Not included |
Applications
1. Pharmaceutical and Therapeutic Use
Rhein is a prominent bioactive compound in traditional Chinese medicine and has shown promising pharmacological effects:
Anti-inflammatory: Inhibits pro-inflammatory cytokines and pathways (e.g., NF-κB), offering relief in conditions like arthritis and colitis.
Anticancer: Induces apoptosis and inhibits proliferation in various cancer cell lines, including liver, breast, and lung cancers.
Antibacterial: Effective against Gram-positive and Gram-negative bacteria, making it a candidate for natural antimicrobial development.
Antioxidant: Scavenges free radicals and protects cells from oxidative stress.
Antidiabetic: Modulates blood glucose and insulin sensitivity; shows potential in diabetic nephropathy treatment.
Hepatoprotective and Nephroprotective: Protects liver and kidney tissues from damage caused by toxins or metabolic stress.
2. Traditional Herbal Medicine
Rhein is a major component in rhubarb-based formulas used for treating constipation, liver disorders, and inflammation.
Used in decoctions and herbal extracts to manage symptoms in traditional Chinese and Ayurvedic medicine.
3. Cosmetics and Skin Care
Incorporated into skin care formulations for its anti-inflammatory and antioxidant properties.
Potential use in anti-aging creams, acne treatments, and products aimed at reducing skin irritation.
4. Biomedical Research
Serves as a lead compound in drug development studies targeting inflammation, cancer, and metabolic diseases.
Used in studying molecular pathways like apoptosis, autophagy, and oxidative damage.
5. Functional Foods and Nutraceuticals
Considered for inclusion in herbal supplements aimed at detoxification and immune support.
Potential role in maintaining gastrointestinal and renal health through natural therapy.
Benefits
✅ Natural Origin: Derived from plants traditionally used in herbal medicine, ensuring compatibility with holistic health approaches.
✅ Multi-functional Pharmacology: Offers a combination of anti-inflammatory, anticancer, and antioxidant benefits.
✅ Low Toxicity (in moderate doses): Preclinical studies indicate favorable safety profiles, especially in herbal forms.
✅ Research Potential: Extensively studied as a model compound for drug development and disease pathway modulation.
Conclusion
Rhein (CAS 478-43-3) is a naturally occurring anthraquinone with wide-ranging therapeutic properties and strong roots in traditional medicine. Its powerful anti-inflammatory, anticancer, and organ-protective effects make it a promising compound for pharmaceutical research, herbal therapeutics, and functional product development. With its multifaceted biological activity and natural derivation, Rhein continues to be a subject of growing interest in modern biomedicine and integrative health solutions.
