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Specifications
| Appearance: | White to off-white crystalline powder |
| Assay: | 98–102% |
| Loss on drying: | 0.5% max |
| Residue on ignition: | 0.1% max |
| Identification: | 1) UV: maximum absorption at 288 nm, minimum absorption at 244 nm 2) IR: corresponds to Firocoxib reference standard spectrum 3) HPLC: retention time of Firocoxib sample is consistent with that of reference standard in ASSAY |
| Related Substances: | P0Z7: 0.5% max Any unspecified impurity: 0.2% max Total impurities: 2% max |
| Residual Solvents: | Ethanol: 5000 ppm max Ethyl acetate: 5000 ppm max Triethylamine: 5000 ppm max Acetonitrile: 410 ppm max Dichloromethane: 600 ppm max |
Applications
1. Veterinary Medicine
A. Dogs (Canine Use)
Osteoarthritis Management: Used for the treatment and control of pain and inflammation associated with osteoarthritis and degenerative joint disease.
Post-operative Pain: Administered to manage acute pain and inflammation following soft tissue or orthopedic surgery.
B. Horses (Equine Use)
Musculoskeletal Disorders: Prescribed for relief of pain and inflammation associated with osteoarthritis, laminitis, and soft tissue injuries.
Pre-surgical and Post-operative Use: Reduces post-surgical discomfort and improves recovery in horses undergoing invasive procedures.
C. Off-label or Research Use in Other Species
Studied for its effects in other large animals and exotic species where selective COX-2 inhibition is beneficial, though usage outside of dogs and horses must comply with veterinary regulations.
Benefits
Selective COX-2 Inhibition: Targets the COX-2 enzyme involved in inflammation while sparing COX-1, which is essential for maintaining gastrointestinal, renal, and platelet functions-this leads to fewer GI side effects compared to traditional NSAIDs.
Effective Pain Relief: Provides strong analgesic and anti-inflammatory effects, improving quality of life and mobility in animals.
Long Duration of Action: Once-daily dosing enhances compliance and convenience for pet owners and veterinarians.
Safe for Long-Term Use (with Monitoring): Can be administered over extended periods with appropriate veterinary supervision and monitoring of renal and hepatic function.
Conclusion
Firocoxib (CAS 189954-96-9) is a veterinary-specific COX-2 selective NSAID widely used to manage pain and inflammation in dogs and horses. Its high selectivity offers effective symptomatic relief with fewer side effects compared to traditional NSAIDs. With its convenient dosing schedule and strong safety profile when used under veterinary guidance, firocoxib has become a first-line therapeutic option for managing osteoarthritis, post-surgical pain, and other inflammatory conditions in companion animals.
