Cinnamaldehyde丨CAS 104-55-2

Cinnamaldehyde丨104-55-2, is an organic compound that plays a significant role in the world of flavors, fragrances, and pharmaceuticals. It is the principal active compound found in cinnamon oil, contributing to the spice's characteristic aroma and flavor. Cinnamaldehyde is a colorless to pale yellow liquid with a warm, sweet, and spicy odor. Chemically, it is an aldehyde derivative of cinnamic acid, with a trans-cinnamyl group attached to the benzene ring. Cinnamaldehyde is widely used in a variety of applications, especially in food, cosmetics, medicine, and pest control, due to its unique properties and health benefits.

This compound is not only valued for its sensory attributes but also for its biological activity, including its antioxidant, anti-inflammatory, antimicrobial, and anticancer properties. Its presence in everyday products ranges from food flavoring to natural remedies and industrial applications, making cinnamaldehyde a versatile compound with broad relevance.

1. Flavoring and Fragrance Industry
Cinnamaldehyde is most commonly known for its role in the food and beverage industry, where it serves as a flavoring agent. It imparts the characteristic spicy-sweet flavor of cinnamon and is commonly used in baked goods, candies, gum, and beverages.
● Food Flavoring: Cinnamaldehyde is a key ingredient in products like cinnamon-flavored pastries, candies, cookies, syrups, and beverages. It is typically used in concentrations of a few parts per million (ppm) to give a strong yet pleasant cinnamon flavor without overpowering the other ingredients.
● Fragrance: Beyond food, cinnamaldehyde is also used in fragrance formulations. Its warm, spicy scent makes it a popular choice in cosmetic products, air fresheners, and cleaning products. It is particularly favored in perfumes, especially in oriental, spicy, and warm fragrance notes.
2. Pharmaceutical and Medicinal Applications
Cinnamaldehyde has gained attention in the pharmaceutical industry due to its bioactive properties. Researchers have found that cinnamaldehyde and its derivatives possess a range of therapeutic benefits, which are utilized in traditional medicine and modern treatments.
● Antimicrobial Properties: Cinnamaldehyde丨104-55-2 has strong antibacterial, antifungal, and antiviral effects. Studies have shown that it can be effective in combating a variety of pathogens, including E. coli, Salmonella, and Candida species. This makes cinnamaldehyde useful in oral hygiene products like toothpastes and mouthwashes, as well as in topical ointments for treating skin infections.
● Anti-inflammatory: Cinnamaldehyde has demonstrated anti-inflammatory properties in scientific studies. It can reduce inflammation by inhibiting the activity of pro-inflammatory mediators like cytokines and prostaglandins, which are involved in conditions such as arthritis and rheumatoid arthritis.
● Antioxidant Effects: The compound exhibits strong antioxidant activity, which is beneficial in protecting cells from oxidative damage. This property helps prevent cellular aging, protects against free radical damage, and can be linked to anti-cancer properties.
● Blood Sugar Regulation: Some studies have suggested that cinnamaldehyde can help in regulating blood sugar levels, potentially benefiting people with type 2 diabetes. It works by influencing key enzymes involved in glucose metabolism, though further research is needed to confirm these effects in clinical settings.
3. Pest Control and Insect Repellents
Cinnamaldehyde丨104-55-2 has been found to exhibit insecticidal and repellent properties, making it useful in natural pest control applications.
● Insect Repellents: The strong aroma of cinnamaldehyde acts as a natural deterrent for insects like mosquitoes, cockroaches, and ants. It is included in various repellent formulations, often as part of essential oils or as an active ingredient in sprays and lotions for outdoor use.
● Antifungal Activity: Cinnamaldehyde has been shown to possess antifungal properties, which makes it useful in preventing the growth of fungi on plants, crops, and even in stored grains. This property makes it a valuable component in natural fungicides.
4. Cosmetic Industry
In addition to its flavoring and fragrance applications, cinnamaldehyde is commonly found in cosmetic products due to its beneficial effects on the skin and its pleasant aroma.
● Skin Care: Cinnamaldehyde has been investigated for its anti-aging and antioxidant benefits in skincare. It is sometimes added to anti-aging creams and moisturizers, where it helps protect the skin from oxidative damage, reduces the appearance of fine lines, and supports overall skin health.
● Hair Care: It is also found in shampoos and hair treatments, where it can contribute to scalp health by reducing the growth of bacteria and fungi. The compound is thought to stimulate hair growth by improving circulation to the scalp.
5. Industrial Applications
Cinnamaldehyde丨104-55-2 is not limited to consumer products but also has important roles in various industrial applications.
● Solvent and Chemical Intermediate: In chemical synthesis, cinnamaldehyde serves as a precursor for various chemical compounds. It can be used to create cinnamon aldehyde derivatives, pharmaceutical intermediates, and flavor compounds.
● Plasticizers and Polymers: Cinnamaldehyde is also used in the production of polymers and plasticizers. Its role as a plasticizer is linked to its ability to modify the flexibility and durability of materials, particularly in the production of polymeric films.

1. Natural and Safe Alternative
Cinnamaldehyde, being derived from cinnamon, is a natural compound. This makes it an attractive alternative to synthetic chemicals in food flavoring, cosmetics, and pest control products. Its low toxicity and natural origin make it an appealing option for consumers seeking eco-friendly and sustainable solutions.
● Non-toxic: Compared to many synthetic chemicals, cinnamaldehyde has a relatively low toxicity profile, making it safe for use in products that are applied topically or ingested in small amounts, like food and cosmetics.
2. Antioxidant and Anti-inflammatory Effects
The antioxidant and anti-inflammatory properties of cinnamaldehyde are particularly beneficial in combating oxidative stress and inflammation, which are involved in a variety of chronic conditions such as cardiovascular diseases, arthritis, and diabetes.
● Cellular Protection: Its ability to neutralize free radicals helps in preventing cell damage associated with aging and various diseases. In combination with its anti-inflammatory effects, cinnamaldehyde could offer a dual benefit for people seeking natural ways to manage chronic conditions.
3. Broad-Spectrum Antimicrobial Activity
Cinnamaldehyde's antimicrobial properties make it highly effective in fighting a wide range of pathogens, including bacteria, fungi, and viruses. This makes it useful in developing natural disinfectants for personal care products, oral hygiene products, and wound care treatments.
● Safety in Use: As a natural antimicrobial agent, Cinnamaldehyde丨104-55-2 can be a safer and more environmentally friendly option compared to traditional chemical disinfectants, which can be harmful to human health and the environment.
4. Natural Pest Control
Cinnamaldehyde's insecticidal properties provide a safer, eco-friendly option for pest control, especially in residential and agricultural settings. It is particularly useful in organic farming where synthetic pesticides are not allowed.
● Reduced Chemical Exposure: The use of cinnamaldehyde in pest control reduces exposure to harmful chemicals and minimizes environmental pollution.
5. Widely Available and Cost-Effective
As cinnamaldehyde is extracted from cinnamon, a widely available spice, it is relatively inexpensive compared to many synthetic alternatives. This makes it an accessible and cost-effective option for various applications, including flavoring, fragrances, and pharmaceuticals.

Cinnamaldehyde丨104-55-2 is a versatile compound with numerous applications in industries ranging from food and cosmetics to pharmaceuticals and agriculture. Its beneficial biological properties, including antioxidant, anti-inflammatory, and antimicrobial activities, make it an important ingredient in health products and natural remedies. Additionally, cinnamaldehyde's natural origin, safety, and low toxicity further enhance its appeal as an eco-friendly and sustainable alternative in various formulations.