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Specifications of 4-tert-Butylbenzyl bromide丨CAS 18880-00-7
|
Appearance |
Dark yellow clear liquid to yellow clear liquid |
|
Purity (HPLC) |
98% min |
|
Impurity at RRT 1.1 |
0.1% max |
|
Water |
0.5% max |
Transport Information of 4-tert-Butylbenzyl bromide丨CAS 18880-00-7
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Parameter |
Specification |
|
UN Number |
3265 |
|
Class |
8 |
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Packing Group |
II |
|
H.S. Code |
2933990099308 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
|
Storage |
Tightly closed. Keep locked up or in an area accessible only to qualified or authorized persons. |
|
Condition to Avoid |
Strong heating. |
|
Package |
Applications of 4-tert-Butylbenzyl bromide丨CAS 18880-00-7
1. Organic Synthesis
Used as an alkylating agent for introducing the 4-tert-butylbenzyl group into molecules, useful in modifying the chemical structure of pharmaceuticals, agrochemicals, and specialty chemicals.
Employed in the synthesis of benzyl-protected intermediates, where the benzyl group acts as a protecting group for hydroxyl or amine functionalities.
Serves as a building block in the preparation of various fine chemicals and pharmaceutical intermediates.
2. Pharmaceutical Industry
Utilized in the synthesis of active pharmaceutical ingredients (APIs) and intermediates.
Can be used to prepare molecules with improved lipophilicity or steric hindrance due to the bulky tert-butyl substituent.
3. Materials Science
Sometimes used in the preparation of functionalized polymers or materials requiring specific aromatic substitution patterns.
Benefits
✅ Selective Alkylation
The para tert-butyl group can provide steric hindrance and electron-donating effects, allowing selective reactions and modifying the reactivity of benzyl bromide.
✅ Versatile Intermediate
Useful intermediate in organic synthesis, enabling the construction of complex molecules.
✅ Improved Stability
The tert-butyl substituent can enhance the stability of derivatives formed, improving shelf life or performance.
Summary
4-tert-Butylbenzyl bromide丨CAS 18880-00-7 is an important alkylating reagent in organic synthesis with wide applications in pharmaceutical intermediate preparation and materials science. Its bulky tert-butyl group enhances selectivity and stability in chemical reactions, making it a valuable compound for designing and producing specialty chemicals.
