4-(4-Hydroxyphenyl)-2-butanone丨CAS 5471-51-2

4-(4-Hydroxyphenyl)-2-butanone丨CAS 5471-51-2, also known as p-Hydroxyphenylacetone or 4-Hydroxyphenyl-2-butanone, is an aromatic ketone compound featuring a hydroxyphenyl group at the para position relative to the ketone. This compound is used as an important intermediate in organic synthesis and is of particular interest in the synthesis of flavors, fragrances, and pharmaceuticals.

1. Fragrance and Flavor Industry
● Flavor and Fragrance Additive: 4-(4-Hydroxyphenyl)-2-butanone丨CAS 5471-51-2 has a pleasant floral, sweet, and fruity aroma, making it an ideal component in cosmetic formulations such as perfumes, lotions, and deodorants.
● Often used in the creation of flavors for food and beverages, contributing to fruity or nutty profiles.
2. Pharmaceutical and Medicinal Chemistry
● Intermediate in Drug Synthesis: The compound serves as an important precursor in the synthesis of various bioactive molecules, including those used for the treatment of neurological and anti-inflammatory disorders.
● Central Nervous System (CNS) drugs: It is involved in the preparation of compounds that modulate neurotransmitter systems, offering therapeutic possibilities for dopaminergic or adrenergic systems.
3. Synthesis of Natural Products
● Phenolic Compounds: It serves as a building block for synthesizing naturally occurring phenolic compounds found in plants, which often exhibit antioxidant, anti-inflammatory, and anticancer activities.
● In particular, derivatives of this compound are used in the synthesis of flavonoids and other phenolic molecules.
4. Polymer Chemistry
● It can be used to modify the chemical structure of polymers, offering functional groups for subsequent reactions in material science, such as in the development of biodegradable plastics or coatings.
5. Chemical Research and Synthesis
● Due to its relatively simple structure and reactive functional groups, it is commonly used as a starting material or precursor in the synthesis of more complex organic molecules and heterocyclic compounds.

1. Flavor and Fragrance Profile
● Its ability to contribute to both sweet, fruity, and floral scents makes it highly valuable in the consumer goods industry, especially for perfumes and food products.
2. Synthetic Versatility
● Hydroxyphenyl group provides diverse opportunities for functionalization in synthetic organic chemistry, enabling the creation of a wide variety of substituted aromatic compounds.
3. Biologically Active Derivatives
● Derivatives of 4-(4-hydroxyphenyl)-2-butanone are bioactive, with some showing potential as antioxidants, anti-inflammatory agents, or neuroprotective compounds, which makes it relevant in drug design.
4. Mild Synthetic Conditions
● It can be synthesized and modified under mild conditions, which reduces the potential for side reactions and degradation, making it highly compatible in a variety of synthetic routes.
5. Widely Applicable in Various Sectors
● Beyond pharmaceuticals and flavoring, its use in polymer chemistry and material science enhances its appeal as a multipurpose compound with cross-industry applicability.

4-(4-Hydroxyphenyl)-2-butanone丨CAS 5471-51-2 is a valuable aromatic intermediate with applications spanning flavors, fragrances, pharmaceuticals, and materials science. Its pleasant scent and synthetic versatility make it a significant compound in both consumer goods and industrial chemistry. Its wide-ranging applications in various industries, along with its potential bioactive properties, highlight its importance in the fields of drug synthesis and chemical manufacturing.