Hangzhou Leap Chem Co., Ltd. is one of the most professional manufacturers and suppliers of methyl 3,3,3-trifluoropropanoate丨cas 18830-44-9 in China. Welcome to wholesale bulk high quality chemical products at competitive price from our factory. If you have any enquiry about custom service, please feel free to email us.
Specifications
|
Appearance |
Colorless or light yellow liquid |
|
Purity |
98% min |
Applications
1. Intermediate in Organic and Fluorine Chemistry
Serves as a key building block in the synthesis of fluorinated compounds, valued for the –CF₃ group's influence on bioactivity, stability, and lipophilicity.
Used to prepare:
Trifluorinated acids, alcohols, and amides
Fluorinated pharmaceuticals and agrochemicals
Specialty polymers and materials
2. Pharmaceutical Development
methyl 3,3,3-trifluoropropanoate丨CAS 18830-44-9 acts as a precursor in the synthesis of fluorinated drug molecules, where the CF₃ group enhances:
Metabolic resistance
Membrane permeability
Binding affinity to biological targets
Commonly used in early-stage medicinal chemistry to introduce trifluoromethyl moieties into bioactive scaffolds.
3. Agrochemical Industry
Incorporated into synthesis routes for herbicides, insecticides, and fungicides, improving their environmental persistence and biological efficacy.
4. Material Science
Starting material in the preparation of fluorinated monomers, which are used to produce durable coatings, resins, and high-performance plastics with hydrophobic and chemically resistant properties.
5. Research and Development
Employed in fluorine chemistry research to explore electronic effects, lipophilicity, and steric modulation in synthetic targets.
Used in structure–activity relationship (SAR) studies for molecule optimization.
Benefits
1. Excellent Fluorine Source
The trifluoromethyl group imparts:
High electronegativity
Strong lipophilicity
Increased thermal and chemical stability
These properties are crucial in drug design and materials engineering.
2. Reactive Ester Functionality
The methyl ester group is easily modified via:
Hydrolysis to carboxylic acid
Reduction to alcohol
Amidation and other derivatizations
Makes the compound synthetically versatile for downstream chemistry.
3. Compact and Efficient
Small molecular size and low molecular weight offer high atom economy, aligning with green chemistry principles in industrial synthesis.
4. Stability and Storage
More stable and easier to handle than free acids or reactive trifluoro intermediates; suitable for long-term storage and transport under ambient conditions.
Conclusion
methyl 3,3,3-trifluoropropanoate丨CAS 18830-44-9 is a highly valuable fluorinated ester used extensively in the pharmaceutical, agrochemical, and materials industries. Its combination of trifluoromethyl functionality and synthetic versatility makes it a preferred intermediate for developing advanced chemical entities. With applications ranging from drug discovery to fluoropolymer synthesis, it plays a key role in modern organic and fluorine-based chemistry.
