Hangzhou Leap Chem Co., Ltd. is one of the most professional manufacturers and suppliers of 2-oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine丨cas 26853-31-6 in China. Welcome to wholesale bulk high quality chemical products at competitive price from our factory. If you have any enquiry about custom service, please feel free to email us.
Specifications
| Appearance | Light yellow to white waxy solid |
| Purity (HPLC) | 98.0% min |
Applications
2-Oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine (POPC) is a naturally derived phospholipid widely used in biochemical, biophysical, and pharmaceutical research. It is a primary component of lipid bilayers, making it essential for the preparation of liposomes, model membranes, and lipid nanoparticles. POPC is used in studies of membrane structure, fluidity, permeability, and protein–lipid interactions, providing a reliable mimic of biological membranes. In drug delivery, it serves as a key component in liposomal formulations, enhancing solubility, stability, and targeted delivery of therapeutic compounds, including nucleic acids, peptides, and small molecules. The compound is also employed in nanoparticle synthesis, membrane protein reconstitution, and lipid-based assay systems, facilitating research into cellular uptake, membrane dynamics, and drug–lipid interactions. Its combination of saturated palmitoyl and unsaturated oleoyl chains allows controlled membrane fluidity and structural stability in experimental systems.
Benefits
POPC offers several advantages in membrane research and pharmaceutical applications. Its amphiphilic structure, with one saturated and one unsaturated fatty acyl chain, provides a fluid yet stable lipid bilayer, closely mimicking natural cell membranes. This enables reproducible studies of membrane protein function, lipid–protein interactions, and membrane permeability. In liposomal formulations, POPC improves encapsulation efficiency and stability of therapeutic agents, while its biocompatibility reduces cytotoxicity and immunogenic responses. The compound's well-defined physicochemical properties allow precise control over vesicle size, membrane composition, and fluidity, which is critical for designing drug delivery systems or model membranes. Additionally, POPC is chemically stable and soluble in common organic solvents, facilitating its handling, storage, and incorporation into experimental systems. Its versatility and reliability make it a standard choice in both fundamental research and applied pharmaceutical development.
Conclusion
2-Oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine is a widely used phospholipid for constructing liposomes, model membranes, and lipid-based delivery systems. Its combination of saturated and unsaturated acyl chains provides membrane fluidity, structural stability, and biocompatibility, making it suitable for membrane biophysics studies, drug delivery research, and lipid–protein interaction experiments. By enabling precise control over membrane properties, POPC supports reproducible experimental results, effective encapsulation of therapeutic agents, and the development of advanced lipid-based technologies.
