3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine丨CAS 34562-31-7

3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine (CAS 34562-31-7) is a dihydropyridine derivative widely used as a synthetic intermediate in pharmaceutical research and organic chemistry. Dihydropyridines are well-known scaffolds in the development of calcium channel blockers, antihypertensive agents, and cardiovascular therapeutics. This compound can serve as a key building block for the synthesis of analogs with improved pharmacological profiles or as a reference compound in structure–activity relationship (SAR) studies. Additionally, it is applied in the design of heterocyclic libraries and in organic synthesis for constructing functionalized dihydropyridine derivatives.

The benefits of 3,5-diethyl-1-phenyl-2-propyl-1,2-dihydropyridine arise from its stable dihydropyridine ring and functional substituents that allow versatile chemical transformations. The ethyl and propyl groups provide steric and lipophilic modulation, which can influence bioactivity and membrane permeability in pharmaceutical applications. The phenyl group contributes to conjugation and electronic stability, supporting selective reactions such as substitution, oxidation, and coupling. Its overall structural versatility makes it suitable for medicinal chemistry optimization, enabling efficient synthesis of derivatives with enhanced pharmacological or physicochemical properties.