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Specifications of N-Isopropylacrylamide丨CAS 2210-25-5
|
Appearance |
White crystal |
|
Purity |
99.0% min |
|
Acid value |
0.5% max |
|
Moisture |
0.5% max |
|
Inhibitor |
500±100 ppm |
Overview
N-Isopropylacrylamide丨CAS 2210-25-5 (NIPAAm) is a temperature-responsive monomer widely used in polymer chemistry to synthesize thermoresponsive polymers. The polymers made from NIPAAm exhibit a sharp phase transition around 32°C (lower critical solution temperature, LCST), meaning they change from hydrophilic to hydrophobic above this temperature. This unique property makes NIPAAm-based polymers useful in various biomedical and industrial applications.
Applications
1. Biomedical and Pharmaceutical Fields
Drug Delivery Systems:
Polymers of NIPAAm are used to create smart drug carriers that release therapeutic agents in response to body temperature changes.
Tissue Engineering:
Hydrogels and scaffolds made from NIPAAm polymers provide temperature-sensitive environments for cell culture and tissue regeneration.
Protein Separation and Purification:
Thermoresponsive polymers help in reversible binding and release of biomolecules by adjusting the temperature.
2. Smart Materials and Coatings
Responsive Surfaces:
NIPAAm polymers are used to create surfaces that switch wettability or adhesiveness with temperature, useful in sensors and actuators.
Self-Healing Materials:
Incorporated in materials that can respond to temperature to repair minor damages.
3. Environmental Applications
Water Treatment:
Thermoresponsive polymers can capture contaminants and release them upon temperature change, aiding in recyclable filtration.
4. Research
Widely used in polymer science to study phase transitions and to develop new smart polymeric systems.
Benefits
✅ Thermoresponsive Behavior
Exhibits a sharp and reversible phase transition near physiological temperatures (~32°C), useful for controlled applications.
✅ Biocompatibility
Polymers derived from NIPAAm are generally biocompatible, making them suitable for medical uses.
✅ Versatility
Can be copolymerized with other monomers to tailor properties like LCST, mechanical strength, and biodegradability.
✅ Controlled Release
Enables on-demand release of drugs or biomolecules triggered by temperature, minimizing side effects.
Summary
N-Isopropylacrylamide丨CAS 2210-25-5 is a key monomer in producing thermoresponsive polymers that undergo reversible changes around body temperature. These materials have broad applications in drug delivery, tissue engineering, smart coatings, and environmental technologies due to their unique temperature-sensitive properties.
