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Specifications
| Characteristics | White or off-white powder |
| Identification | Complies |
| Specific rotation | -50° to -56° |
| Water | 6.5% to 8.5% |
| Residue on ignition | 0.2% max |
| Impurity A | 0.5% max |
| Impurity B | 0.5% max |
| Impurity C | 0.5% max |
| Impurity D | 0.5% max |
| Other single impurity | 0.2% max |
| Total impurities | 2% max |
| Isonicotinamide | 1% max |
| Glacial acetic acid | 5000 ppm max |
| Acetone | 5000 ppm max |
| Dichloromethane | 600 ppm max |
| Assay (on anhydrous) | 98% min |
| Bacterial endotoxins | 0.13 EU/mg max |
Applications
Cephalonium (CAS 5575-21-3) is a first-generation cephalosporin antibiotic primarily used in veterinary medicine. It is most commonly applied in the treatment and prevention of bacterial infections in dairy cattle, particularly in cases of bovine mastitis. Administered through intramammary infusion, cephalonium effectively targets Gram-positive bacteria such as Staphylococcus aureus and Streptococcus species, which are common pathogens in mastitis. Its extended activity profile makes it suitable for both therapeutic and prophylactic use, including dry cow therapy to prevent infections during the non-lactating period. Beyond veterinary applications, it is also studied in microbiology research as a model cephalosporin compound for understanding β-lactam activity and resistance mechanisms.
Benefits
The benefits of cephalonium are strongly linked to its antibacterial spectrum and practical utility in livestock management. Its β-lactam structure provides potent activity against key Gram-positive pathogens, supporting rapid resolution of infections and improved udder health in dairy cattle. The compound's stability and formulation for intramammary administration ensure effective distribution and retention within the udder, enabling both treatment and long-term prophylaxis. This contributes to higher milk quality, reduced economic losses from mastitis, and overall herd health management. Furthermore, by reducing the prevalence of bacterial infections, it helps minimize the need for repeated antibiotic use, supporting responsible veterinary practices.
Conclusion
In summary, cephalonium is a valuable veterinary antibiotic with specific applications in managing and preventing bovine mastitis. Its benefits include strong activity against mastitis-causing pathogens, suitability for both therapeutic and prophylactic use, and contribution to improved milk production and animal health. As livestock industries continue to emphasize productivity and welfare, cephalonium remains an important tool in maintaining udder health and ensuring the quality and safety of dairy products.
