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Specifications
| Grade: | China Pharmacopoeia 2020 |
| Appearance: | Off-white or light yellow crystalline powder |
| Identification: | Positive reaction The retention time for the main peaks of sample should be the same as the retention time for reference standard. It gives the reaction of Sulfate. |
| Water: | 5.0% max |
| pH: | 1.6-2.6 |
| Clarity of Solution: | Clear or not more opalescent than reference suspension I |
| Color of Solution: | Colorless or not more intensely colored than reference solution Y7 |
| Related Substances: | 5,6,7,8-Tetrahydroquinoline ≤ 2.0% Any other impurity ≤ 1.0% Total impurities ≤ 3.0% |
| Sulfated Ash: | 0.3% max |
| Heavy Metals: | 20 ppm max |
| Particle Size: | 90% should be less than 10 μm |
| Visible foreign matter: | Complies |
| Sterility: | Complies |
| Bacterial Endotoxins: | 0.20 EU/mg max |
| Assay: | Contains Cefquinome (C23H24N6O5S2) ≥ 80.0%, calculated on the anhydrous substance |
Applications
Cefquinome sulfate is a fourth-generation cephalosporin antibiotic primarily used in veterinary medicine for the treatment of bacterial infections in livestock, including cattle, pigs, and poultry. It is effective against a broad spectrum of Gram-positive and Gram-negative bacteria, making it suitable for addressing respiratory, urinary, gastrointestinal, and systemic infections. Cefquinome sulfate is formulated into injectable solutions, powders for reconstitution, and medicated feed additives to provide flexible dosing options for veterinary practitioners. In research, it is utilized to study antimicrobial resistance, pharmacokinetics, and therapeutic efficacy in animal models. Its high potency and broad-spectrum activity make it a valuable tool for improving animal health and productivity, ensuring food safety and quality in animal-derived products.
Benefits
Cefquinome sulfate offers several advantages due to its enhanced stability, broad antibacterial spectrum, and rapid bactericidal action. The compound is highly effective against multi-drug resistant bacterial strains commonly encountered in livestock, reducing the risk of severe infections and improving treatment outcomes. Its water solubility and stability as a sulfate salt allow easy formulation into injectables and feed additives, facilitating accurate dosing and convenient administration. Cefquinome sulfate demonstrates low toxicity and minimal side effects in target animals, supporting animal welfare and compliance with veterinary regulations. Additionally, its pharmacokinetic properties, including good tissue penetration and extended half-life, ensure effective therapeutic levels are maintained, reducing dosing frequency and improving treatment adherence.
Conclusion
Cefquinome sulfate is a potent veterinary cephalosporin antibiotic with broad-spectrum antibacterial activity, widely used to manage infections in livestock. Its efficacy against resistant pathogens, stability, and versatility in formulation make it an essential tool in veterinary medicine for ensuring animal health, improving productivity, and maintaining food safety. Continued research and application of cefquinome sulfate support responsible antibiotic use and the development of effective infection-control strategies in animal husbandry.
