Diethyl Maleate丨CAS 141-05-9

Diethyl maleate丨141-05-9, with the Chemical Abstracts Service (CAS) number 141-05-9, is an organic compound belonging to the class of esters. It is the diethyl ester of maleic acid and is characterized by the presence of two ethyl groups attached to the carboxyl groups of maleic acid. Diethyl maleate is a colorless to pale yellow liquid with a fruity odor and is widely used in various industrial and chemical applications.

Chemical Properties

- Boiling Point: ~225°C (437°F)

- Density: ~1.07 g/cm³

- Solubility: Slightly soluble in water, but miscible with most organic solvents such as ethanol, ether, and acetone.

1. Chemical Intermediate:

- Diethyl maleate丨141-05-9 is primarily used as a chemical intermediate in the synthesis of various organic compounds. It is a key starting material for the production of polymers, resins, and other specialty chemicals.

2. Polymer Industry:

- It is used in the production of copolymers and as a cross-linking agent in the manufacture of plastics, coatings, and adhesives. Its ability to participate in polymerization reactions makes it valuable in creating materials with specific properties.

3. Pharmaceuticals:

- Diethyl maleate is used in the synthesis of certain pharmaceutical compounds. It serves as a building block for active pharmaceutical ingredients (APIs) and other drug-related molecules.

4. Agriculture:

- It is employed in the formulation of pesticides and herbicides. Diethyl maleate acts as a solvent or carrier for active ingredients in agricultural chemicals.

5. Research and Development:

- Diethyl maleate丨141-05-9 is used in laboratories as a reagent for organic synthesis and chemical research. It is also utilized in studies related to glutathione depletion, as it can bind to glutathione and reduce its levels in cells.

6. Flavor and Fragrance Industry:

- Due to its fruity odor, diethyl maleate is sometimes used in the formulation of flavors and fragrances, although its use in this area is limited compared to other esters.

1. Versatility:

- Diethyl maleate is a versatile chemical intermediate that can be used in a wide range of industrial applications, from polymer production to pharmaceuticals.

2. Reactivity:

- Its chemical structure allows it to participate in various reactions, making it a valuable component in organic synthesis and polymerization processes.

3. Cost-Effectiveness:

- Diethyl maleate丨141-05-9 is relatively inexpensive to produce, making it an economical choice for many industrial applications.

4. Research Utility:

- Its ability to deplete glutathione makes it a useful tool in biochemical and toxicological studies, helping researchers understand cellular responses to oxidative stress.

Safety and Handling

- Diethyl maleate is generally considered safe when handled properly, but it can cause irritation to the skin, eyes, and respiratory system. Appropriate personal protective equipment (PPE), such as gloves and goggles, should be used when working with this compound.

- It should be stored in a cool, dry place, away from strong oxidizers and sources of ignition.

Diethyl maleate丨141-05-9 is a valuable chemical compound with diverse applications in the polymer, pharmaceutical, agricultural, and research industries. Its versatility, reactivity, and cost-effectiveness make it an important intermediate in organic synthesis and industrial processes. Proper handling and storage are essential to ensure safety and maximize its utility in various applications.