Orotic Acid Monohydrate丨CAS 50887-69-9

Orotic acid monohydrate丨50887-69-9 (also known as orotic acid or pyrimidine-2,4-dicarboxylic acid) is a naturally occurring organic compound that plays a pivotal role in pyrimidine metabolism. It is a precursor in the biosynthesis of nucleotides, which are essential for the formation of DNA and RNA. Orotic acid is a derivative of pyrimidine, one of the building blocks of the nucleic acids.

The monohydrate form of orotic acid (with one water molecule per molecule of orotic acid) is commonly used in biochemical research, pharmaceutical formulations, and various health supplements. Due to its role in the synthesis of nucleotides, it has potential applications in various fields, such as genetics, cardiology, nephrology, sports nutrition, and metabolic health.

1. Pyrimidine Nucleotide Synthesis
Orotic acid monohydrate丨50887-69-9 is a precursor to uracil and other pyrimidine nucleotides, which are vital components of DNA and RNA. It is involved in the de novo biosynthesis of uridine monophosphate (UMP), which is then converted into other nucleotides necessary for cellular processes like cell division, protein synthesis, and genetic material replication.
● Research Tool in Genetics: Orotic acid is commonly used in genetic research to study nucleotide metabolism, particularly in studies related to cell proliferation, gene expression, and DNA replication. Its role in nucleic acid synthesis makes it an important compound in the study of cell growth and genetic disorders related to nucleotide deficiencies.
2. Treatment of Orotic Aciduria
Orotic aciduria is a rare genetic disorder characterized by impaired conversion of orotic acid into uridine. This leads to an accumulation of orotic acid in the body and can cause symptoms such as growth retardation, megaloblastic anemia, and liver dysfunction.
● Therapeutic Use: Orotic acid monohydrate has been used as a treatment for orotic aciduria to supplement uridine production. Administering orotic acid helps to bypass the defective enzymes and correct the metabolic imbalance, thus improving the symptoms of the disorder.
3. Sports Nutrition and Endurance Enhancement
Orotic acid is sometimes included in sports supplements for its potential role in enhancing endurance and physical performance. Its involvement in nucleotide metabolism is thought to support ATP production (the energy currency of cells), and it may help maintain cellular energy levels during intense physical activity.
● Energy Production and Muscle Function: Some studies suggest that orotic acid supplementation may support muscle endurance and recovery by improving the synthesis of nucleotides required for muscle repair and mitochondrial function.
● Preventing Muscle Fatigue: By contributing to the synthesis of nucleotides and improving energy metabolism, orotic acid may help reduce the onset of muscle fatigue and promote faster recovery after prolonged exercise.
4. Support for Liver Function
Orotic acid is involved in liver health, particularly in the synthesis of compounds required for fat metabolism. Some research has suggested that orotic acid may have a protective effect on the liver by supporting lipid metabolism and assisting in the detoxification processes that take place in liver cells.
● Liver Disease Management: Orotic acid supplementation has been investigated for its potential benefits in conditions such as fatty liver disease and hepatitis, where it may help promote liver cell regeneration and improve overall liver function.
5. Cardiovascular Health
There is some evidence to suggest that orotic acid may play a role in cardiovascular health. It has been observed that orotic acid is involved in lipid metabolism, which could affect the lipid profile and cholesterol levels in the body. This makes orotic acid a candidate for managing conditions like hyperlipidemia (high cholesterol).
● Cholesterol Regulation: By influencing lipid metabolism, orotic acid could potentially help reduce cholesterol levels and promote heart health, although further research is needed to confirm its role in cardiovascular therapies.
6. Potential Anticancer Properties
In recent years, orotic acid and its derivatives have been studied for their potential anticancer effects. Since orotic acid plays a role in DNA synthesis and cell division, it is thought that modulating its levels may influence cancer cell growth.
● Cancer Cell Growth Inhibition: Some studies suggest that altering orotic acid levels in the body could influence the proliferation of cancer cells. This could potentially lead to the development of therapies that target tumor growth by modulating nucleotide metabolism.
● Tumor Suppression: By influencing cell cycle regulation and nucleotide metabolism, orotic acid might act as a tumor suppressor in certain types of cancers. However, this is still an area of ongoing research, and clinical applications in oncology have not been fully established.
7. Cosmetic and Skin Health
Orotic acid monohydrate丨50887-69-9 has applications in cosmetic formulations, particularly in products aimed at promoting skin health and anti-aging. Its role in cell division and regeneration makes it an attractive compound for supporting skin repair.
● Cell Regeneration: Orotic acid is thought to contribute to the regeneration of skin cells by supporting DNA repair and collagen synthesis, which are crucial for maintaining healthy, youthful skin.
● Anti-aging: As a promoter of cellular growth and repair, orotic acid may help in the prevention of wrinkles and skin sagging, which are associated with aging and environmental damage. Some anti-aging products incorporate orotic acid to support skin renewal and improve skin elasticity.

1. Supports Nucleotide Synthesis

As a precursor to uridine and other pyrimidine nucleotides, orotic acid monohydrate is vital for maintaining the integrity and functionality of DNA and RNA. This helps ensure proper cellular division and gene expression, both of which are critical for health and growth.

2. Treats Orotic Aciduria

Orotic acid supplementation is a key treatment for orotic aciduria, a genetic disorder that causes a deficiency in sialic acid and affects multiple systems in the body. Supplementing with orotic acid helps normalize metabolic functions in individuals suffering from this condition.

3. Enhances Physical Performance

Orotic acid may enhance muscle endurance, physical performance, and muscle recovery by supporting energy metabolism and nucleotide synthesis, potentially benefiting athletes and individuals involved in high-intensity physical activities.

4. Improves Liver Health

By influencing lipid metabolism and aiding in the synthesis of essential compounds, orotic acid may promote liver regeneration and help manage liver diseases such as fatty liver and hepatitis.

5. Cardiovascular Support

Orotic acid monohydrate丨50887-69-9 may have benefits for heart health by regulating lipid metabolism and potentially improving cholesterol levels. This could make it a helpful tool for those at risk of cardiovascular disease.

6. Anticancer Potential

Emerging research suggests that orotic acid could be useful in the development of cancer therapies, particularly by modulating cell proliferation and nucleotide synthesis to suppress tumor growth.

Orotic acid monohydrate丨50887-69-9 is a versatile compound with a range of applications in biochemical research, medical treatments, and therapeutic formulations. Its primary role in the biosynthesis of pyrimidine nucleotides makes it essential for DNA synthesis, cell division, and gene expression. Additionally, its therapeutic applications extend to treating genetic disorders like orotic aciduria, improving liver health, enhancing physical performance, and potentially aiding in cardiovascular health and cancer treatment. While further research is needed in some areas, the potential benefits of orotic acid monohydrate make it a promising compound in the fields of medicine, pharmaceuticals, and health supplements.