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Specifications
| Grade | USP2025 |
| Appearance | Slightly yellow crystal powder |
| Assay | 99–101% |
| Identification A | The retention time of the major peak of the sample solution corresponds to that of the standard solution |
| Identification B | IR spectra of sample compares qualitatively to the IR spectra of the standard |
| Melting Point | 60–62 °C |
| Loss on drying | 0.2% max |
| Residue on ignition | 0.1% max |
| Specific rotation | -1.0 to +1.0 deg |
| Related substances (single impurity) | 0.1% max |
| Total impurities | 2.0% max |
| Limit of polymer content | 2.0% max |
| Residual solvents – Cyclohexane | 3880 ppm max |
| Residual solvents – Ethyl acetate | 500 ppm max |
| Residual solvents – Toluene | 20 ppm max |
| Particle size | 100% through 40 mesh |
| Heavy metals | 10 ppm max |
| Ca | 1 ppm max |
| As | 1 ppm max |
| Lead | 3 ppm max |
| Mercury | 0.1 ppm max |
| Total aerobic microbial count | 1000 CFU/g max |
| Yeast & Mold | 100 CFU/g max |
| E. Coli | Absence/g |
| Salmonella | Absence/g |
| Staphylococcus aureus | Absence/g |
Applications
DL-Thioctic acid, also known as alpha-lipoic acid, is widely used in nutraceuticals, pharmaceuticals, food supplements, cosmetics, and biochemical research. In health supplements and pharmaceutical formulations, it is incorporated for its antioxidant properties and is often included in products aimed at supporting metabolic health, cellular protection, and overall wellness. It is used in formulations targeting oxidative stress management and as a cofactor in energy-producing metabolic pathways. In cosmetics and skincare, DL-Thioctic acid is added to creams, serums, and anti-aging products due to its ability to neutralize free radicals, improve skin texture, and support barrier protection. The compound is also utilized in biochemical studies related to mitochondrial function, redox regulation, and enzyme mechanisms where its dithiolane ring plays a key role in catalytic processes. Industrial applications include its use as an antioxidant additive in certain specialized chemical and polymer formulations.
Benefits
DL-Thioctic acid provides several valuable benefits that contribute to its broad adoption across multiple sectors. Its strong antioxidative capacity enables it to scavenge reactive oxygen species and help protect biological structures from oxidative damage. A unique feature of DL-Thioctic acid is its solubility in both aqueous and lipid environments, allowing it to function in diverse cellular compartments and support overall redox balance. It can regenerate other antioxidants, such as vitamins C and E, enhancing the synergistic effects of antioxidant networks. In cosmetic applications, it supports a healthier skin appearance by reducing oxidative stress and improving firmness and texture. In chemical and industrial contexts, its stability and reactivity allow it to act as an efficient stabilizing component in selected formulations.
Conclusion
DL-Thioctic acid is a multifunctional compound used in supplements, pharmaceuticals, skincare products, and biochemical research. Its potent antioxidant activity, dual solubility, and supportive role in metabolic and redox processes make it a valuable ingredient for health, cosmetic, and scientific applications. Overall, DL-Thioctic acid offers reliable functionality, versatility, and performance across a wide range of formulations and research contexts.
