Dextran Sulfate Sodium丨CAS 9011-18-1

Dextran sulfate sodium丨9011-18-1 is a sulfated polysaccharide derived from dextran, a natural polysaccharide made from glucose. DSS is widely used in biomedical research, particularly for its anti-inflammatory, anticoagulant, and immunomodulatory properties. It is most notably employed in studies involving inflammatory diseases, colitis models, and cell signaling pathways.

1. Inflammatory Disease Models
● Induction of experimental colitis: DSS is widely used to induce acute and chronic colitis in animal models for studying inflammatory bowel diseases (IBD), such as ulcerative colitis. It helps researchers evaluate the effectiveness of novel drugs aimed at treating inflammatory bowel disease (IBD).
● Research into autoimmune diseases: It is used in preclinical studies of autoimmune diseases to understand immune responses and inflammation processes.
2. Anticoagulant and Antithrombotic Agent
● DSS has anticoagulant properties and is used in blood clotting studies.
● It inhibits thrombin and factor Xa, two key components involved in blood clot formation.
● In research on thromboembolic diseases, DSS is investigated as a potential treatment or preventive agent for stroke and other cardiovascular conditions.
3. Antiviral and Antibacterial Research
● Due to its sulfate groups, Dextran sulfate sodium丨9011-18-1 exhibits antiviral activity, particularly against viruses like HIV. It interacts with viral particles to inhibit viral entry into host cells.
● DSS is also explored in antibacterial research, where it may help in preventing bacterial adhesion to epithelial cells or as a carrier for drug delivery in antibiotic therapies.
4. Drug Delivery Systems
● DSS is utilized in drug delivery systems, particularly for targeted therapies. It can be used to form complexes with drugs, improving their solubility, stability, and bioavailability.
● It is also part of nano-carriers for gene delivery applications, where DSS acts as an important component in the delivery of RNA or DNA molecules into cells.
5. Cellular and Molecular Research
● DSS is used in cell culture studies, particularly in experiments related to cell signaling and cell surface interactions.
● It is used to study the effects of sulfated polysaccharides on immune cells, and it plays a role in understanding how cells respond to inflammatory stimuli and modulate immune function.
6. Research in Gastroenterology
● DSS is frequently employed in studies related to gastrointestinal health, particularly in understanding the pathogenesis of intestinal inflammation and gut microbiota changes.
● It aids in exploring the microbiome-gut-brain axis and testing potential therapies for gut-related disorders.

✅ Induces Colitis for Disease Modeling
● A key tool in experimental colitis models, DSS is essential for investigating treatments for inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease.
✅ Anti-inflammatory Effects
● Dextran sulfate sodium丨9011-18-1 has been shown to modulate the immune response and reduce inflammation, making it useful in research on autoimmune diseases and other inflammatory conditions.
✅ Anticoagulant Properties
● By inhibiting blood clotting factors, DSS may be used in the study of thrombosis and stroke prevention therapies.
✅ Antiviral and Antibacterial Activity
● Exhibits antiviral properties, particularly against HIV, and potential antibacterial effects, useful in infectious disease research.
✅ Potential for Drug Delivery and Gene Therapy
● Serves as an effective carrier for drugs and genes, increasing drug solubility and targeting specific tissues, enhancing treatment efficacy.
✅ Modulation of Immune Responses
● Investigated for its effects on immune cells, DSS plays a role in studying immunomodulatory effects that could lead to novel therapeutic applications in cancer immunotherapy or autoimmune conditions.

Dextran sulfate sodium丨9011-18-1 is a versatile compound with broad applications across biomedical research, particularly in the study of inflammatory diseases, autoimmunity, and drug delivery systems. Its anti-inflammatory, anticoagulant, and antiviral properties make it an invaluable tool in preclinical studies, while its potential in drug and gene delivery enhances its use in the pharmaceutical industry. Overall, DSS continues to be a valuable asset in advancing the understanding of immune system regulation and therapeutic innovation.