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Specifications
| Appearance: | White to off white solid or powder, no obvious mechanical impurities |
| Purity (GC): | 99.0% min |
| Assay (Titration): | 98.0% to 102.0% |
| Identification: | IR conforms to standard spectrum |
| Water: | 1.0% max. |
| Clarity of solution: | Turbidity: No.3 Turbidity Standard Solution max. |
| PH: | 11.0 to 12.4 |
| Residue on ignition: | 0.5% max. |
| Fe ion: | 10 ppm max. |
| Largest single impurity: | 0.05% max. |
| Total impurities: | 1.0% max. |
| Toluene: | 0.5% max. |
Transport Information
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Parameter |
Specification |
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UN Number |
2923 |
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Class |
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Packing Group |
II |
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H.S. Code |
2933990099306 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
|
Storage |
Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons. hygroscopic |
|
Condition to Avoid |
Avoid moisture. |
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Package |
Manufacturing Information
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Parameter |
Specification |
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Capacity |
5MT/month |
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Frequency |
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Main Export Countries |
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Capacity/Batch |
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Experience |
Production since 2016 |
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Stock |
Applications
1. Chelating Agent in Coordination Chemistry
Cyclen is widely used as a macrocyclic ligand that strongly coordinates with metal ions, especially transition metals and lanthanides.
Forms highly stable complexes with metals such as Gadolinium (Gd³⁺), Copper (Cu²⁺), Nickel (Ni²⁺), Zinc (Zn²⁺), and others.
These complexes are utilized in various chemical and biological applications due to their high specificity and stability.
2. Medical and Diagnostic Uses
Cyclen derivatives complexed with Gadolinium are key components in MRI contrast agents (e.g., Gadoterate meglumine).
The high stability reduces toxicity by preventing free metal ion release in the body.
3. Catalysis
Used as a ligand in homogeneous catalysis to improve reaction selectivity and efficiency.
Enhances catalytic activity in oxidation, hydrogenation, and other metal-catalyzed processes.
4. Research and Development
Serves as a building block for synthesizing functionalized macrocycles.
Studied in supramolecular chemistry for constructing molecular cages, sensors, and ion transporters.
5. Environmental Chemistry
Used in metal ion sequestration and recovery from industrial waste streams.
Helps in selective removal of heavy metals due to strong metal-binding properties.
Benefits
✅ Strong Metal Binding Affinity
Macrocyclic effect imparts exceptional thermodynamic and kinetic stability to metal complexes.
✅ Biocompatibility
Cyclen-based complexes are relatively non-toxic and biocompatible, important for medical applications.
✅ Versatile Functionalization
Nitrogen atoms can be functionalized to tailor ligand properties for specific applications.
✅ Improved Selectivity
The rigid cyclic structure enhances selectivity toward particular metal ions.
✅ Chemical Stability
Stable under physiological and environmental conditions, ensuring durability in various uses.
Conclusion
Cyclen (CAS 294-90-6) is a pivotal macrocyclic ligand in coordination chemistry, offering exceptional metal ion binding stability and versatility. Its applications span from medical imaging, catalysis, and environmental remediation to advanced chemical research. Cyclen's unique properties make it a foundation molecule for designing metal complexes with high specificity and safety profiles.
