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Specifications
| Appearance | White to light yellow powder |
| Identification | Conforms |
| PH | 3.5~7.5 |
| Water | 9.0~12.0% |
| Individual impurity | 2.0% max |
| Total impurities | 5.0% max |
| Amoxicillin (C16H19N3O5S) (based on drying) | 695 µg/mg min |
| Clavulanic acid (C8H9NO5) | 176 µg/mg min |
| Amoxicillin:Clavulanic acid | 3.6~4.4 |
Applications
The Amoxicillin-Potassium Clavulanate combination is a widely used broad-spectrum antibiotic formulation in human and veterinary medicine. It combines the β-lactam antibiotic amoxicillin with clavulanic acid, a β-lactamase inhibitor, to overcome bacterial resistance mediated by β-lactamase-producing strains. This combination is commonly prescribed for respiratory tract infections, urinary tract infections, skin and soft tissue infections, and other bacterial infections caused by susceptible pathogens. It is also applied in clinical research to study antibiotic resistance mechanisms, optimize dosing regimens, and develop improved formulations such as oral suspensions, tablets, and intravenous preparations.
Benefits
The benefits of the Amoxicillin-Potassium Clavulanate combination arise from its synergistic action. Amoxicillin effectively inhibits bacterial cell wall synthesis, while clavulanate protects amoxicillin from enzymatic degradation by β-lactamase-producing bacteria, broadening the spectrum of activity against resistant strains. The combination is well-tolerated, exhibits predictable pharmacokinetics, and provides effective oral and parenteral therapeutic options. Its ability to treat infections that are otherwise resistant to standard β-lactam antibiotics improves clinical outcomes, reduces treatment failure, and decreases the likelihood of prolonged or recurrent infections.
Conclusion
The Amoxicillin-Potassium Clavulanate combination is a critical antibiotic formulation that extends the efficacy of amoxicillin against β-lactamase-producing bacteria. Its broad-spectrum activity, synergistic mechanism, and clinical versatility make it essential in managing a wide range of bacterial infections. By combining potent antibacterial action with resistance protection, this combination remains a cornerstone in both medical therapy and antibiotic development.
