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Specifications
| Appearance: | Light yellow powder or crystalline powder |
| Purity (HPLC): | 99% min |
| Identify: | The IR spectrum of the sample should be consistent with the spectrum of the reference substance |
| Solubleness: | Insoluble in water |
| Loss on Drying: | 5.0% max |
| Related Substance: | A: Single impurity: 0.1% max B: Total impurities: 0.5% max |
| Residue on Ignition: | 0.2% max |
Transport Information
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Specification |
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H.S. Code |
2942000000313 |
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Stability & Reactivity |
The solution in DMSO can be stored stably for one month at -20 ° C. |
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Storage |
Sealed in cold and dry place,2-8 degC |
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Condition to Avoid |
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Applications
7-Ethyl-10-hydroxycamptothecin (CAS 86639-52-3), commonly known as SN-38, is a potent topoisomerase I inhibitor and an active metabolite of the anticancer prodrug irinotecan. It is widely used in oncology research and pharmaceutical development for the treatment of various cancers, including colorectal, lung, ovarian, and gastric cancers. Its mechanism of action involves stabilizing the DNA-topoisomerase I complex, preventing DNA re-ligation, and ultimately inducing apoptosis in rapidly dividing cells. In addition to direct therapeutic use in experimental settings, 7-ethyl-10-hydroxycamptothecin serves as a reference standard for pharmacokinetic studies, drug formulation development, and targeted drug delivery research.
Benefits
The benefits of 7-ethyl-10-hydroxycamptothecin stem from its exceptional potency and selectivity as a topoisomerase I inhibitor. It exhibits significantly higher cytotoxic activity than irinotecan, making it a crucial molecule for developing next-generation anticancer therapies. Its unique structure, featuring a lactone ring system, provides strong binding affinity to the enzyme-DNA complex, ensuring effective inhibition of tumor cell proliferation. Additionally, research into its conjugates and prodrug derivatives has enabled improvements in solubility, bioavailability, and targeted delivery, thereby reducing systemic toxicity. Its well-characterized pharmacology and high efficacy make it a valuable tool in both clinical and preclinical cancer studies.
Conclusion
7-Ethyl-10-hydroxycamptothecin is a highly potent and biologically significant anticancer compound that plays a central role in cancer therapy and drug development. Its strong topoisomerase I inhibition, high cytotoxicity against tumor cells, and utility in drug delivery research make it indispensable in modern oncology. By serving as both a therapeutic agent and a research benchmark, it continues to drive innovation in the development of safer and more effective cancer treatments.
