5-Bromo-2-methylpyridin-3-amine丨CAS 914358-73-9

5-Bromo-2-methylpyridin-3-amine (CAS 914358-73-9) is a heterocyclic compound widely used as an intermediate in pharmaceutical and agrochemical synthesis. Its pyridine core and amino functionality make it a valuable building block for the development of bioactive molecules, including kinase inhibitors, receptor modulators, and other therapeutic agents. It is also employed in medicinal chemistry for structure–activity relationship (SAR) studies, facilitating the design of derivatives with optimized potency, selectivity, and pharmacokinetic profiles. Additionally, it serves as a precursor for the synthesis of functionalized heterocycles, dyes, and fine chemicals.

The benefits of 5-Bromo-2-methylpyridin-3-amine arise from its reactive amino group and halogen-substituted pyridine scaffold, which allow versatile chemical transformations such as cross-coupling, condensation, and nucleophilic substitution reactions. The bromine atom at position 5 facilitates selective functionalization, while the methyl group influences steric and electronic properties to modulate reactivity and stability. Its solubility in common organic solvents and compatibility with standard synthetic protocols make it practical for laboratory and industrial applications, supporting efficient synthesis of bioactive and functional compounds.