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Specifications
| Item | Specification |
| Appearance | Light yellow liquid |
| Assay | 99% min |
| Melting Point | 22–24 °C |
| Moisture | 0.5% max |
Transport Information
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Parameter |
Specification |
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UN Number |
3265 |
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Class |
8 |
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Packing Group |
II |
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H.S. Code |
2909309090307 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. |
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Condition to Avoid |
Avoid moisture. |
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Package |
Manufacturing Information
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Experience |
Production since 2005 |
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Stock |
Applications
4-(Trifluoromethoxy)benzyl bromide (CAS 50824-05-0) is a halogenated aromatic compound widely used as an intermediate in pharmaceutical, agrochemical, and fine chemical synthesis. Its bromide functionality enables nucleophilic substitution reactions, making it useful for introducing the 4-(trifluoromethoxy)benzyl moiety into various target molecules. In medicinal chemistry, it is applied to synthesize bioactive compounds, including enzyme inhibitors, receptor ligands, and other drug candidates where the trifluoromethoxy group enhances metabolic stability and lipophilicity. It is also used in agrochemical research to prepare herbicides, fungicides, and insecticides with improved potency. Additionally, it serves as a building block for creating fluorinated aromatic derivatives in specialty chemicals and material sciences.
Benefits
The benefits of 4-(trifluoromethoxy)benzyl bromide stem from its reactive bromide and the presence of the trifluoromethoxy group. The bromide atom acts as a versatile leaving group, allowing selective substitution or cross-coupling reactions to generate a wide variety of functionalized molecules. The trifluoromethoxy group improves chemical and metabolic stability, increases lipophilicity, and can modulate electronic properties, enhancing bioactivity and pharmacokinetic profiles in medicinal compounds. Its combination of reactivity and fluorinated properties makes it a valuable intermediate for rapid and efficient synthesis of high-performance chemicals.
Conclusion
In summary, 4-(trifluoromethoxy)benzyl bromide is a multifunctional intermediate used in pharmaceuticals, agrochemicals, and fine chemical synthesis. Its applications include the preparation of bioactive molecules, fluorinated derivatives, and agrochemical agents, while its benefits lie in its reactive bromide, enhanced stability, and ability to improve lipophilicity and bioactivity. This compound remains a key building block for modern synthetic and medicinal chemistry.
