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Specifications of 4-Bromopyrazole丨CAS 2075-45-8
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Appearance |
Almost white to white crystal powder |
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Assay (HPLC) |
98% min |
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Identification |
Working standard sample |
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Moisture Content |
1% max |
Transport Information of 4-Bromopyrazole丨CAS 2075-45-8
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Parameter |
Specification |
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UN Number |
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Class |
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Packing Group |
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H.S. Code |
2933199090999 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Keep container tightly closed. Store in a cool and shaded area. Keep under inert gas |
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Condition to Avoid |
Exposure to air. |
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Package |
Manufacturing Information of 4-Bromopyrazole丨CAS 2075-45-8
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Parameter |
Specification |
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Capacity |
2MT/month |
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Frequency |
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Main Export Countries |
US, EU |
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Capacity/Batch |
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Experience |
Production since 1998 |
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Stock |
Applications
1. Pharmaceutical Intermediates
4-Bromopyrazole丨CAS 2075-45-8 is commonly used as a building block in the synthesis of:
Heterocyclic pharmaceuticals (e.g., kinase inhibitors, antivirals, CNS agents)
Brominated precursors for creating diversified analogs via cross-coupling reactions (Suzuki, Buchwald-Hartwig, etc.)
Bioactive pyrazole derivatives, a core motif in numerous drugs due to their anti-inflammatory, antimicrobial, and anticancer properties
2. Agrochemical Synthesis
Intermediate in the development of fungicides, herbicides, and insecticides
The bromopyrazole unit can be modified to introduce targeted biological activity in crop protection agents
3. Material Science
Used in functional materials research, particularly for producing ligands in coordination chemistry and metal-organic frameworks (MOFs)
4. Academic and Medicinal Chemistry Research
Serves as a substrate for SAR (structure–activity relationship) studies
Valuable in medicinal chemistry toolkits for lead optimization and analog generation
Benefits
✅ Synthetic Versatility
The bromo group at the 4-position is highly reactive in cross-coupling reactions, making it a prime candidate for C–C and C–N bond formation
Enables access to a broad range of functionalized pyrazoles-a crucial scaffold in medicinal chemistry
✅ Pharmacologically Relevant Scaffold
Pyrazole rings are privileged structures in drug discovery due to their planar, aromatic nature and favorable pharmacokinetic profiles
Functionalization at the 4-position allows modulation of biological activity, solubility, and receptor binding affinity
✅ Stable and Easy to Handle
Solid form with a reasonable shelf life and stability under standard lab conditions
Compatible with standard purification and reaction techniques (e.g., recrystallization, chromatography)
Conclusion
4-Bromopyrazole丨CAS 2075-45-8 is a valuable intermediate in organic synthesis, particularly in drug development, agrochemical research, and materials science. Its reactivity at the bromine-substituted site and the pharmacologically rich pyrazole ring make it a strategic choice for chemists looking to develop novel compounds with therapeutic or industrial potential.
