3-(4-Piperidinyl)-1,2-benzisoxazole Hydrochloride丨CAS 84163-22-4

3-(4-Piperidinyl)-1,2-benzisoxazole hydrochloride (CAS 84163-22-4) is a heterocyclic compound primarily used as a pharmaceutical intermediate. Its benzisoxazole and piperidine moieties make it a key building block in the synthesis of antipsychotic and neuroactive drugs, particularly those targeting dopamine and serotonin receptor systems. It is widely applied in medicinal chemistry research programs aiming to develop therapeutic agents for psychiatric and neurological conditions, including schizophrenia, depression, and anxiety disorders. In addition, it is used in structure–activity relationship (SAR) studies to design novel drug candidates, offering insights into receptor binding and pharmacological properties. Beyond pharmaceuticals, its use extends to specialty fine chemical synthesis, where heteroaryl intermediates are required.

The benefits of 3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride lie in its stability, versatility, and efficiency as a synthetic intermediate. The hydrochloride form provides enhanced solubility and handling, supporting both laboratory-scale and industrial-scale synthesis. Its structural framework allows chemists to efficiently construct drug molecules with high receptor affinity and therapeutic potential, streamlining development processes in neuroscience-related drug discovery. By enabling selective modification of the benzisoxazole and piperidine components, it reduces synthetic complexity and improves yields of target compounds. This makes it not only a valuable tool for pharmaceutical innovation but also a cost-effective and reliable option for manufacturing advanced intermediates.