1-(1-(1H-imidazole-1-carbonyl)piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one丨CAS 1373116-06-3

This compound is primarily used as an advanced intermediate in pharmaceutical research, especially in the development of heterocycle-based drug candidates. Its fused imidazo[4,5-b]pyridine core and additional imidazole and piperidine functionalities make it suitable for designing molecules targeting kinase pathways, GPCRs, and other biologically relevant receptors. It is also explored in medicinal chemistry programs aimed at developing anticancer, antiviral, anti-inflammatory, and CNS-active agents. The compound's multifunctional heterocyclic structure provides multiple points for derivatization, enabling structure–activity relationship (SAR) studies and facilitating the synthesis of libraries for high-throughput screening. Beyond drug discovery, it is occasionally used in chemical biology, probe design, and synthesis of functionalized heterocyclic scaffolds for advanced materials research.

The benefits of this molecule arise from its structurally rich and pharmacologically relevant heterocyclic framework. The imidazo[4,5-b]pyridin-2-one system offers strong hydrogen-bonding capability, enhancing binding affinity and selectivity in biological targets. The appended imidazole adds additional coordination properties, making the compound suitable for tuning electronic characteristics and improving receptor interaction profiles. The piperidinyl moiety contributes to solubility, metabolic stability, and balanced physicochemical properties desirable for drug-like compounds. Together, these features make the compound highly versatile for medicinal chemistry optimization, enabling researchers to adjust potency, target selectivity, pharmacokinetics, and ADME characteristics through strategic derivatization.