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Specifications
| Grade | Pharma grade |
| Appearance | Colorless transparent liquid or crystal |
| Assay (anhydrous basis, C4H10O) | 99.8% min |
| Relative Density | 0.778 ~ 0.783 |
| Freezing Point | 24°C min |
| Identification (Infrared Absorption Spectrum) | Consistent with reference spectrum (SDS No.: 506) |
| Acidity | Conforms |
| Clarity and Color of Solution | Conforms |
| Absorbance 215 nm | 1.0 max |
| Absorbance 230 nm | 0.5 max |
| Absorbance 250 nm | 0.1 max |
| Absorbance 300 nm | 0.01 max |
| Acetone | 0.010% max |
| 2-Butanol | 0.150% max |
| n-Butanol | 0.020% max |
| Nonvolatile matter (Leftover residue) | 1 mg (0.001%) max |
| Easy oxide | Conforms |
| Carbonyl Compounds | 0.01% max |
| Moisture | 0.1% max |
| Heavy Metals | 2 ppm max |
| Arsenic Salt | 0.000015% max |
Applications
tert-Butanol is a versatile organic alcohol widely used in chemical synthesis, solvent applications, and pharmaceutical research. It serves as a reagent and intermediate in the preparation of tert-butyl esters, ethers, and other functionalized compounds. In organic synthesis, it is employed in Grignard reactions, nucleophilic substitutions, and as a stabilizer for peroxides and radical initiators. Its use as a solvent is common in polymer chemistry, chromatography, and industrial formulations due to its moderate polarity and miscibility with water and organic solvents. In pharmaceutical and biochemical research, tert-butanol is utilized in crystallization processes, lyophilization, and sample preparation where its volatility and low freezing point provide operational advantages. Additionally, it is applied in the production of specialty chemicals, flavoring agents, and laboratory reagents.
Benefits
The benefits of tert-Butanol stem from its chemical stability, moderate polarity, and physical properties. Its tertiary structure imparts resistance to oxidation and rearrangement under normal laboratory conditions, making it a reliable solvent and reagent. Its volatility and low melting point facilitate easy removal after reactions, aiding purification and crystallization processes. tert-Butanol is compatible with a wide range of organic and aqueous systems, supporting diverse synthetic and analytical applications. Its role as a precursor in the synthesis of tert-butyl derivatives allows selective protection and functionalization of sensitive molecules. Additionally, it is relatively safe to handle with proper laboratory protocols, making it a convenient choice for industrial and research environments.
Conclusion
tert-Butanol is a multifunctional alcohol used extensively as a solvent, chemical reagent, and intermediate in organic synthesis. Its chemical stability, physical properties, and versatility enable a wide range of applications in pharmaceuticals, polymer chemistry, and fine chemicals. By supporting efficient reactions, easy purification, and flexible solvent usage, tert-Butanol continues to be an essential compound in modern chemical research and industrial processes.
