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Specifications
| Grade | EP10.0 |
| Appearance | Hard, waxy mass, or powder or white or almost white, unctuous flakes |
| Solubility | Practically insoluble in water, soluble in methylene chloride, partly soluble in hot ethanol (96%) |
| Acid value | 4.0 max |
| Iodine Value | 3.0 max |
| Saponification Value | 145~165 |
| Identification | A. Melting point: 65~77℃ B. Composition of fatty acids (See test) C. It complies with the assay (content of diacylglycerols) |
| Free glycerol | 1.0% max |
| Water | 1.0% max |
| Total ash | 0.1% max |
| Composition of fatty acids | Palmitic acid: 3.0% max Stearic acid: 5.0% max Arachidic acid: 10.0% max Behenic acid: 83.0% min Erucic acid: 3.0% max Lignoceric acid: 3.0% max |
| Assay | Monoacylglycerols: 15.0%~23.0% Dioacylglycerols: 40.0%~60.0% Triacylglycerols: 21.0%~35.0% |
Applications
Glyceryl Dibehenate is primarily used in pharmaceutical formulations as a matrix former for sustained-release tablets and controlled-release drug delivery systems. Its hydrophobic nature allows it to modulate drug release rates and improve the stability of lipophilic active ingredients. It is also employed as a solid lipid in lipid-based drug delivery systems, including solid lipid nanoparticles (SLNs) and self-emulsifying drug delivery systems (SEDDS), enhancing the bioavailability of poorly water-soluble drugs. In the nutraceutical and supplement industry, it acts as a binder, excipient, or solidifying agent in softgels and capsules. Additionally, in cosmetics and personal care products, glyceryl dibehenate functions as an emollient, thickener, and stabilizer in creams, lotions, and ointments.
Benefits
The benefits of Glyceryl Dibehenate include its chemical and thermal stability, biocompatibility, and ability to form solid lipid matrices. It provides controlled and sustained release of active ingredients, improving therapeutic efficacy and patient compliance in pharmaceutical applications. Its hydrophobic and waxy nature enhances the stability of lipophilic compounds, prevents oxidation, and reduces degradation. In nutraceuticals and cosmetics, it contributes to smooth texture, improved spreadability, and formulation stability. It is non-toxic, non-irritant, and generally regarded as safe (GRAS), making it suitable for oral, topical, and parenteral applications.
Conclusion
Glyceryl Dibehenate is a versatile lipid excipient widely used in pharmaceuticals, nutraceuticals, and personal care products. Its solid lipid properties, stability, and biocompatibility make it ideal for controlled drug release, formulation stabilization, and improving the performance of lipophilic ingredients. As the demand for advanced delivery systems and stable formulations grows, Glyceryl Dibehenate remains a critical component in modern pharmaceutical and cosmetic applications.
