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Specifications of Bacitracin丨CAS 1405-87-4
|
Property |
Specification |
|
Grade |
EP10.5 |
|
Appearance |
White or almost white, hygroscopic powder |
|
Microbial assay (dried basis) |
60 IU/mg |
|
Identification |
HPLC, Conforms; Meets composition test; No white precipitate |
|
pH |
6–7 |
|
Loss on drying |
5% max |
|
Sulfated Ash |
1% max |
|
Content of Bacitracin A |
45% min |
|
Sum of Bacitracin A, B1, B2, B3 |
77% min |
|
Sum of impurities L, N |
8% max |
|
Impurity E |
4% max |
|
Impurity A |
3.5% max |
|
Impurity B |
3% max |
|
Impurity M |
3% max |
|
Impurity C |
2.5% max |
|
Sum of impurities O, P, Q |
2.5% max |
|
Sum of impurities F, G |
2% max |
|
Impurity H |
1% max |
|
Any other impurity |
2% max |
|
Total impurities |
23% max |
|
Total viable aerobic count |
100 cfu/g max |
|
Particle size |
Min. 99% ≤ 20 µm by volume |
Transport Information of Bacitracin丨CAS 1405-87-4
|
Parameter |
Specification |
|
UN Number |
|
|
Class |
|
|
Packing Group |
|
|
H.S. Code |
2941909099302 |
|
Stability & Reactivity |
The product is chemically stable under standard ambient conditions (room temperature). |
|
Storage |
Tightly closed. Store in a closed, dry, ventilated place. 2-8℃ |
|
Condition to Avoid |
Avoid moisture. |
|
Package |
Manufacturing Information of Bacitracin丨CAS 1405-87-4
|
Parameter |
Specification |
|
Capacity |
1MT/month |
|
Frequency |
|
|
Main Export Countries |
EU, Asia, Africa, South America |
|
Capacity/Batch |
|
|
Experience |
Production since 2009 |
|
Stock |
100kg |
Overview
Bacitracin丨CAS 1405-87-4 is a polypeptide antibiotic produced by Bacillus subtilis and Bacillus licheniformis. It is primarily active against Gram-positive bacteria and is commonly formulated as a topical treatment for preventing or treating infections in minor wounds, burns, and skin conditions. Bacitracin is known for its low systemic absorption, making it especially suitable for dermatological and ophthalmic use.
Applications of Bacitracin丨CAS 1405-87-4
1. Topical Antibiotic for Skin Infections
Bacitracin is widely used in over-the-counter ointments and creams to treat:
● Minor cuts, scrapes, and burns: Prevents infection by inhibiting bacterial cell wall synthesis.
● Dermatitis and localized bacterial skin infections: Effective against Staphylococcus and Streptococcus species.
Often combined with other antibiotics (e.g., neomycin or polymyxin B) for broader-spectrum coverage.
2. Ophthalmic Preparations
Used in eye ointments for treating bacterial conjunctivitis and blepharitis, due to its efficacy and gentle action on sensitive tissues.
● Sterile formulations: Designed for safe application to ocular surfaces.
3. Veterinary Medicine
Bacitracin丨CAS 1405-87-4 is also used in veterinary formulations for treating skin infections in animals and previously as a growth promoter in livestock (though restricted in many countries due to resistance concerns).
● Topical sprays and powders: Help control infection in wounds and surgical sites for pets and livestock.
4. Pharmaceutical Manufacturing
Employed as a preservative or bioburden control agent in certain pharmaceutical processes and cell culture media, particularly where Gram-positive contamination is a risk.
Benefits of Bacitracin丨CAS 1405-87-4
1. Effective Against Gram-Positive Bacteria
Bacitracin丨CAS 1405-87-4 inhibits bacterial cell wall synthesis, making it potent against Gram-positive pathogens like Staphylococcus aureus, including some MRSA strains in topical applications.
2. Low Systemic Toxicity
When used topically, bacitracin exhibits minimal systemic absorption, reducing the risk of systemic side effects and making it safe for short-term skin application.
3. Synergy with Other Antibiotics
Often formulated in triple antibiotic ointments for synergistic and broader antimicrobial activity, reducing the chance of resistance development.
4. Ease of Use and Accessibility
Available in non-prescription (OTC) forms, bacitracin is a convenient first-line treatment for preventing infection in minor wounds and injuries.
