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Specifications
| Appearance: | White crystals or powder |
| Assay: | 98% min |
| Solubility: | Easily soluble in water, insoluble in ether |
| Appearance of solution: | Dissolve 0.5 g in 10 ml of water, and the solution should be clear |
| Identification: | IR and TLC |
| MS and NMR: | Should Comply |
| Specific rotation (c = 5, after 5h in H2O): | +13° to +16° |
| Residue on ignition: | 0.1% max |
| TLC: | Should be one spot |
| Heavy metal: | 20ppm max |
Applications
1. Food and Beverage Industry
Low-Calorie Sweetener
D-Allose has around 80% the sweetness of sucrose but only a fraction of the calories. It can be used in sugar-free, low-glycemic foods and beverages, especially for diabetic or ketogenic-friendly products.
Functional Ingredient
It may serve as a functional food ingredient for promoting anti-obesity and antioxidant effects, supporting health claims in wellness-oriented products.
2. Pharmaceutical and Biomedical Research
Anti-Cancer Potential
D-Allose has shown in vitro anti-tumor activity, especially against some human cancer cell lines, by inducing cell cycle arrest and apoptosis. It is being researched as a potential cancer therapeutic or adjuvant.
Neuroprotection and Anti-inflammatory
Some studies suggest D-Allose can reduce oxidative stress and inflammation in neural tissues, making it of interest in neurodegenerative disease research.
Blood Sugar Regulation
It may inhibit intestinal α-glucosidase, leading to delayed carbohydrate absorption, thus helping in blood glucose control and insulin regulation.
3. Cosmetics and Personal Care
Skin Moisturizer
D-Allose's humectant properties make it suitable for use in skincare formulations to retain moisture and improve skin texture.
Anti-aging and Anti-inflammatory Effects
Its antioxidant and cell protection benefits may support formulations designed for anti-aging, skin barrier protection, and redness reduction.
4. Biotechnology and Research
Cell Culture Studies
Used in cell viability and metabolic pathway experiments due to its unique properties and structural similarity to glucose.
Sugar Metabolism Research
As a rare sugar, D-Allose is frequently used in studies exploring carbohydrate metabolic pathways, enzyme specificity, and glycosylation processes.
5. Agriculture and Plant Sciences
Plant Growth Regulation
Research shows D-Allose can influence plant physiology, including germination inhibition, oxidative stress modulation, and growth regulation, which may aid in agricultural biotechnology or crop protection strategies.
Benefits
✅ Low-Calorie Sugar Substitute
Offers a sweet taste similar to table sugar but with significantly fewer calories.
Suitable for diabetics and individuals on weight management or keto diets.
✅ Blood Glucose Control
Reduces postprandial blood sugar spikes by inhibiting carbohydrate-digesting enzymes.
May help improve insulin sensitivity.
✅ Antioxidant and Anti-Inflammatory Properties
Neutralizes reactive oxygen species (ROS).
Potential to mitigate inflammation and oxidative stress in tissues.
✅ Potential Anticancer Activity
Inhibits cell proliferation and induces apoptosis in certain tumor cells.
May be used as a non-toxic adjunct in chemotherapy or cancer prevention.
✅ Safe and Natural
Naturally occurring, non-toxic, and well-tolerated in dietary doses.
Not metabolized the same way as glucose, minimizing metabolic load.
✅ Versatile Applications
Usable in food, health supplements, pharmaceutical formulations, and cosmetics.
Stable under various processing conditions, making it viable for commercial formulations.
Conclusion
D-Allose (CAS 2595-97-3) is an emerging rare sugar with broad potential across food, pharmaceutical, cosmetic, and research industries. Its low glycemic index, antioxidant properties, and biological activity make it a standout ingredient for health-oriented products. Though currently limited by production cost and availability, advances in enzymatic synthesis and rare sugar technology are rapidly expanding its commercial potential.

