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Specifications
|
Appearance |
Light yellow to off-white crystalline powder |
|
Content |
98.5% min |
|
Loss on drying |
1.0% max |
|
Residue on ignition |
0.1% max |
|
Heavy metals |
20 ppm max |
|
Storage Condition |
Sealed, keep in normal temperature place |
Applications of Prulifloxacin丨CAS 123447-62-1
1. Urinary Tract Infections (UTIs)
Commonly used to treat complicated and uncomplicated UTIs, including pyelonephritis.
Effective against E. coli and Klebsiella, which are frequent uropathogens.
2. Respiratory Tract Infections
Used in acute exacerbations of chronic bronchitis (AECB) and community-acquired pneumonia (CAP).
3. Gastrointestinal Infections
Treats infectious diarrhea, particularly when caused by bacterial pathogens sensitive to fluoroquinolones.
4. Sexually Transmitted Infections (STIs)
Sometimes prescribed for gonorrhea and non-gonococcal urethritis, though resistance patterns must be monitored.
5. Skin and Soft Tissue Infections
Used off-label or selectively in certain skin infections, especially when caused by susceptible Gram-negative organisms.
Benefits
✅ Prodrug Design for Enhanced Absorption
Prulifloxacin is converted to ulifloxacin in the intestine, offering better oral bioavailability compared to some other fluoroquinolones.
✅ Once-Daily Dosing
Long half-life (~10–12 hours) allows for convenient once-daily administration, improving patient compliance.
✅ Broad Antibacterial Spectrum
Covers both aerobic Gram-negative and Gram-positive pathogens, making it suitable for empirical therapy in many cases.
✅ Low Incidence of Gastrointestinal Side Effects
Generally well tolerated with a lower risk of nausea or diarrhea than some other quinolones.
Summary
Prulifloxacin丨CAS 123447-62-1 is a prodrug fluoroquinolone antibiotic with broad-spectrum antibacterial activity, convenient once-daily dosing, and good oral absorption. It's primarily used to treat urinary, respiratory, and gastrointestinal infections, especially in regions where it is approved and resistance levels are managed. As with all antibiotics, appropriate use is essential to limit resistance development.
