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Specifications
| Grade: | FCCⅤ |
| Appearance: | White crystalline powder |
| Assay (Titration): | 98.5 to 101.5% |
| Specific rotation [α]D20: | +25.2 to +25.8 deg |
| Lead: | 5 mg/kg max |
| Loss on drying: | 0.5% max |
| Residue on ignition: | 0.25% max |
Applications
1.1 Pharmaceutical Industry
Used as a pharmaceutical intermediate for the synthesis of various drugs, especially those related to the nervous system.
The hydrochloride form improves stability and solubility, facilitating drug formulation.
Plays a role in producing glutamate receptor agonists/antagonists and other neuroactive compounds.
1.2 Nutritional Supplements and Food Industry
Acts as a source of glutamic acid, an important amino acid for metabolism and neurotransmission.
Used in nutritional formulations for clinical nutrition, parenteral feeding, and amino acid supplements.
Glutamic acid derivatives are involved in flavor enhancement (e.g., MSG).
1.3 Biochemical and Molecular Biology Research
Serves as a substrate or reagent in enzymatic studies involving glutamate metabolism.
Utilized in cell culture media as a nutrient.
Important for studying neurotransmission and amino acid transport mechanisms.
1.4 Cosmetic Industry
Incorporated in skin care products for its moisturizing and pH balancing properties.
Supports skin hydration and enhances the formulation of amino acid-based cosmetics.
Benefits
2.1 Enhanced Solubility and Stability
The hydrochloride salt form improves the water solubility and shelf life, making it suitable for pharmaceutical and biological applications.
2.2 Biocompatibility and Bioavailability
Being a natural amino acid, it is biocompatible and readily metabolized by the body.
Supports cell function, neurotransmission, and protein synthesis.
2.3 Versatility
Useful in a wide range of applications, from drug development to nutrition and cosmetics.
Serves as a key building block in peptide synthesis and other biochemical processes.
Conclusion
L-(+)-Glutamic Acid Hydrochloride (CAS 138-15-8) is an essential amino acid derivative widely used in pharmaceuticals, nutrition, biochemical research, and cosmetics. Its enhanced solubility and stability as a hydrochloride salt make it a preferred form for various applications. As a natural metabolite, it supports key physiological functions including neurotransmission and protein synthesis, underscoring its significance in health and disease management. This compound's broad applicability and biocompatibility continue to make it an important ingredient across multiple industries.
