Trehalose丨CAS 99-20-7

Trehalose丨CAS 99-20-7 is a naturally occurring, non-reducing disaccharide composed of two glucose molecules linked via an α,α-1,1-glycosidic bond. It is known for its high stability, non-hygroscopic nature, and mild sweetness, making it valuable across food, pharmaceutical, cosmetic, and biotechnology industries.

1. Food Industry
● Sweetener and Texturizer: Used as a low-sweetness sugar substitute with a clean taste, excellent solubility, and stability under heat and acid.
● Moisture retention: Helps preserve texture in baked goods, confectionery, and frozen foods.
● Flavor enhancer: Stabilizes flavors and aromas during processing and storage.
● Shelf-life extension: Reduces browning and oxidation of lipids and proteins in foods.
2. Pharmaceuticals and Biotechnology
● Protein and enzyme stabilizer: Trehalose丨CAS 99-20-7 protects proteins and biomolecules from degradation caused by heat, desiccation, or freezing.
oUsed in vaccines, protein-based drugs, and biological reagents.
● Lyoprotectant: Commonly used in lyophilization (freeze-drying) to stabilize peptides, antibodies, and other biologics.
● Drug carrier: May be used in drug delivery systems to protect active ingredients.
● Neuroprotective research: Studied for its ability to reduce protein aggregation and oxidative stress in models of neurodegenerative diseases like Alzheimer's, Huntington's, and Parkinson's.
3. Cosmetics and Personal Care
● Moisturizing agent: Trehalose retains water and protects skin cells from dehydration.
● Anti-aging and protective properties: Guards against oxidative damage and UV-induced stress.
● Found in products like:
oFacial creams
oLotions
oHair conditioners
oSunscreens
4. Cell Preservation and Cryoprotection
● Cryoprotectant: Used in the cryopreservation of cells, tissues, and organs by protecting membranes and proteins from cold-induced damage.
● Widely used in laboratory research, biobanking, and stem cell storage.
5. Agricultural and Environmental Applications
● Enhances drought resistance in crops by acting as a natural osmoprotectant.
● May improve survival of beneficial microbes in soil and composting applications.

1. High Stability
● Non-reducing sugar: Doesn't participate in Maillard reactions, making it ideal for products requiring heat treatment.
● Resistant to acid hydrolysis: Maintains structure and functionality under low pH.
2. Biocompatibility and Safety
● Non-toxic and non-cariogenic (does not promote tooth decay).
● Recognized as Generally Recognized As Safe (GRAS) by FDA and approved in the EU and Japan for food use.
3. Protective Effects on Biomolecules
● Stabilizes:
oProteins
oLipid bilayers
oNucleic acids
● Mimics protective effects found in nature (e.g., organisms that survive desiccation).
4. Mild Sweetness and Low Glycemic Impact
● Lower sweetness and glycemic index compared to sucrose, suitable for diabetic-friendly and weight-conscious formulations.

Trehalose丨CAS 99-20-7 is a versatile disaccharide that offers functional, protective, and health-related benefits across a wide spectrum of industries. From food preservation and biopharmaceutical stability to cosmetic hydration and cryoprotection, trehalose plays a pivotal role in modern formulations due to its unique stability, biocompatibility, and functional performance.