Hangzhou Leap Chem Co., Ltd. is one of the most professional manufacturers and suppliers of podophyllotoxin丨cas 518-28-5 in China. Welcome to wholesale bulk high quality chemical products at competitive price from our factory. If you have any enquiry about custom service, please feel free to email us.
Specifications
| Appearance | White powder |
| Purity | 98% min (HPLC) |
| Assay | 98% min (HPLC) |
| Heavy metal | 20 ppm max |
| Loss on drying | 2% max |
| Residue on ignition | 0.1% max |
| Specific optical rotation | -131 ~ -134 deg |
| Benzene | 100 ppm max |
| Related substances | 2.0% max |
| Identification | Positive |
| Melting point | 181 ~ 185 degC |
Transport Information
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H.S. Code |
2932209090302 |
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Stability & Reactivity |
Very hygroscopic |
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Storage |
2-8°C |
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Manufacturing Information
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Experience |
Production since 2015 |
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Applications
1. Antineoplastic Agent Precursor
Podophyllotoxin is a natural product isolated from plants such as Podophyllum peltatum (Mayapple) and Podophyllum emodi.
It serves as the lead compound for semisynthetic derivatives like etoposide and teniposide, which are widely used chemotherapy drugs.
These derivatives inhibit DNA topoisomerase II, disrupting DNA replication in cancer cells.
2. Topical Antiviral and Antimitotic Agent
Used in topical formulations for treating genital warts caused by human papillomavirus (HPV).
Exhibits antimitotic properties by binding to tubulin, thereby inhibiting microtubule assembly and cell division.
3. Research Tool
Employed in cell biology and pharmacology to study mechanisms of:
Microtubule dynamics
Cell cycle regulation
Apoptosis induction
4. Pharmaceutical Intermediate
Used as a starting material or scaffold in developing new anticancer and antiviral compounds.
Benefits
✅ Potent Biological Activity
Exhibits strong antimitotic and antiviral properties.
✅ Versatile Lead Compound
Structural framework inspires development of multiple clinically important chemotherapeutic agents.
✅ Natural Origin
Derived from renewable plant sources.
✅ Selective Action
Targets rapidly dividing cells, making it effective in cancer and wart treatment.
Conclusion
Podophyllotoxin (CAS 518-28-5) is a powerful natural lignan with significant antimitotic and antiviral activities. As the precursor to vital chemotherapeutic agents such as etoposide, it plays a pivotal role in cancer treatment. Its natural origin and unique mechanism make it a cornerstone compound in pharmacology and drug development. Despite its potency, safe handling and controlled application are essential due to its toxicity. Podophyllotoxin continues to inspire new therapeutic innovations in oncology and antiviral therapy.
