4-Piperidinecarboxylic Acid, 1-methyl-, Hydrochloride (1:1)丨CAS 71985-80-3

4-Piperidinecarboxylic acid, 1-methyl-, hydrochloride (1:1) (CAS 71985-80-3) is a piperidine-based amino acid derivative widely used as a pharmaceutical intermediate and building block in medicinal chemistry. It serves as a key precursor for the synthesis of bioactive molecules, including enzyme inhibitors, receptor modulators, and central nervous system (CNS) agents. The compound is also applied in the development of peptide analogs and heterocyclic derivatives where the piperidine scaffold provides structural rigidity and enhanced pharmacokinetic properties. Additionally, its hydrochloride salt form improves solubility and stability, making it suitable for laboratory synthesis and formulation studies.

The benefits of this compound arise from its functional versatility, structural stability, and solubility. The piperidine ring provides a rigid, cyclic scaffold that enhances molecular recognition and binding affinity in biological targets. The carboxylic acid group allows for further derivatization via amide formation or esterification, facilitating the synthesis of diverse therapeutic analogs. The methyl substitution on the nitrogen and the hydrochloride salt enhance solubility and chemical stability, supporting efficient handling and incorporation into synthetic pathways. These properties make it a practical and effective intermediate for medicinal chemistry applications.