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What is Vilazodone?

Nov. 2021/6/21 15:27:35 By LEAP Chem

This is part of our ongoing series helping consumers better understand pharmaceutical ingredients. We translate the pharmaceutical science, explain the drug natures, and give you an honest advice, so you can choose the right drugs for your family!

Molecular formula of Vilazodone: C26H27N5O2

Chemical IUPAC Name: 5-(4-[4-(5-Cyano-1H-indol-3-yl)butyl]piperazin-1-yl)benzofuran-2-carboxamide

CAS No.: 163521-12-8

Structural Formula:

 163521-12-8.png

Vilazodone

Vilazodone is a serotonergic antidepressant developed by Merck KGaA and licensed by Clinical Data, a biotech company purchased by Forest Laboratories in 2011. Vilazodone was approved in 2011 by the FDA for use in the United States to treat major depressive disorder. In some ways, its activity can be conceptualized as a combination of an SSRI and buspirone.

Vilazodone HCl is 2-benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-, hydrochloride (1:1). Its molecular weight is 477.99. In addition to the active ingredient, VIIBRYD tablets contain the following inactive ingredients: lactose monohydrate, microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide, polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, FD&C Blue #1 (40 mg only), FD&C Yellow #6 (20 mg only) and FD&C Red #40 (10 mg only).

 

Uses of Vilazodone

According to two eight-week, randomized, double-blind, placebo-controlled trials in adults, vilazodone elicits an antidepressant response after one week of treatment. After eight weeks, subjects assigned to vilazodone 40 mg daily dose (titrated over two weeks) experienced a higher response rate than the group given placebo (44% vs 30%, P = .002). Remission rates for vilazodone were not significantly different versus placebo. Vilazodone is used for treating depression. It may also be used for other conditions as determined by your doctor.

Vilazodone is an antidepressant. It is thought to work by increasing the activity of one of the brain chemicals (serotonin), which helps elevate mood. It is an SSRI (selective serotonin reuptake inhibitor) and partial serotonin receptor agonist. It works by helping to restore the balance of certain natural substances in the brain (neurotransmitters such as serotonin). This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living.

 

Side Effects of Vilazodone

Diarrhea, nausea, vomiting, dizziness, trouble sleeping, decreased interest in sex, or changes in sexual ability may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: numbness/tingling, tremor, restlessness, inability to keep still, difficulty concentrating, confusion, memory problems, weakness, unsteadiness, pounding heartbeat.

 

References

https://en.wikipedia.org/wiki/Vilazodone

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278186/

https://www.ncbi.nlm.nih.gov/pubmed/19764890

https://www.ncbi.nlm.nih.gov/pubmed/26496736


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